2.50
Hdl Handle:
http://hdl.handle.net/10033/306701
Title:
Microstructure of calcium stearate matrix pellets: a function of the drying process.
Authors:
Schrank, Simone; Kann, Birthe; Windbergs, Maike; Glasser, Benjamin J; Zimmer, Andreas; Khinast, Johannes; Roblegg, Eva
Abstract:
Drying is a common pharmaceutical process, whose potential to modify the final drug and/or dosage form properties is often underestimated. In the present study, pellets consisting of the matrix former calcium stearate (CaSt) incorporating the active pharmaceutical ingredient ibuprofen were prepared via wet extrusion and spheronization. Subsequent drying was performed by either desiccation, fluid-bed drying, or lyophilization, and the final pellets were compared with respect to their microstructure. To minimize the effect of solute ibuprofen molecules on the shrinking behavior of the CaSt, low ibuprofen loadings were used, as ibuprofen is soluble in the granulation liquid. Pellet porosity and specific surface area increased during desiccation, fluid-bed drying, and lyophilization. The inlet-air temperature during fluid-bed drying affected the specific surface area, which increased at lower inlet-air temperatures rather than the pellet porosity. The in vitro dissolution profiles were found to be a nonlinear function of the specific surface area. Overall, the microstructure, including porosity, pore size, and specific surface area, of CaSt pellets was a strong function of the drying conditions.
Affiliation:
Institute for Process and Particle Engineering, Graz University of Technology, Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, University of Graz, Graz, Austria.
Citation:
Microstructure of calcium stearate matrix pellets: a function of the drying process. 2013, 102 (11):3987-97 J Pharm Sci
Journal:
Journal of pharmaceutical sciences
Issue Date:
Nov-2013
URI:
http://hdl.handle.net/10033/306701
DOI:
10.1002/jps.23707
PubMed ID:
23983150
Type:
Article
Language:
en
ISSN:
1520-6017
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorSchrank, Simoneen
dc.contributor.authorKann, Birtheen
dc.contributor.authorWindbergs, Maikeen
dc.contributor.authorGlasser, Benjamin Jen
dc.contributor.authorZimmer, Andreasen
dc.contributor.authorKhinast, Johannesen
dc.contributor.authorRoblegg, Evaen
dc.date.accessioned2013-12-11T08:40:59Z-
dc.date.available2013-12-11T08:40:59Z-
dc.date.issued2013-11-
dc.identifier.citationMicrostructure of calcium stearate matrix pellets: a function of the drying process. 2013, 102 (11):3987-97 J Pharm Scien
dc.identifier.issn1520-6017-
dc.identifier.pmid23983150-
dc.identifier.doi10.1002/jps.23707-
dc.identifier.urihttp://hdl.handle.net/10033/306701-
dc.description.abstractDrying is a common pharmaceutical process, whose potential to modify the final drug and/or dosage form properties is often underestimated. In the present study, pellets consisting of the matrix former calcium stearate (CaSt) incorporating the active pharmaceutical ingredient ibuprofen were prepared via wet extrusion and spheronization. Subsequent drying was performed by either desiccation, fluid-bed drying, or lyophilization, and the final pellets were compared with respect to their microstructure. To minimize the effect of solute ibuprofen molecules on the shrinking behavior of the CaSt, low ibuprofen loadings were used, as ibuprofen is soluble in the granulation liquid. Pellet porosity and specific surface area increased during desiccation, fluid-bed drying, and lyophilization. The inlet-air temperature during fluid-bed drying affected the specific surface area, which increased at lower inlet-air temperatures rather than the pellet porosity. The in vitro dissolution profiles were found to be a nonlinear function of the specific surface area. Overall, the microstructure, including porosity, pore size, and specific surface area, of CaSt pellets was a strong function of the drying conditions.en
dc.language.isoenen
dc.rightsArchived with thanks to Journal of pharmaceutical sciencesen
dc.titleMicrostructure of calcium stearate matrix pellets: a function of the drying process.en
dc.typeArticleen
dc.contributor.departmentInstitute for Process and Particle Engineering, Graz University of Technology, Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Graz, Austria; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology, University of Graz, Graz, Austria.en
dc.identifier.journalJournal of pharmaceutical sciencesen

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