2.50
Hdl Handle:
http://hdl.handle.net/10033/310994
Title:
Synthesis of the spiroketal core of integramycin.
Authors:
Prusov, Evgeny V
Abstract:
A concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.
Affiliation:
Department of Medicinal Chemistry, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germany
Citation:
Synthesis of the spiroketal core of integramycin. 2013, 9:2446-50 Beilstein J Org Chem
Journal:
Beilstein journal of organic chemistry
Issue Date:
2013
URI:
http://hdl.handle.net/10033/310994
DOI:
10.3762/bjoc.9.282
PubMed ID:
24367411
Type:
Article
Language:
en
ISSN:
1860-5397
Appears in Collections:
publications of the department medicinal chemistry (MCH)

Full metadata record

DC FieldValue Language
dc.contributor.authorPrusov, Evgeny Ven
dc.date.accessioned2014-01-07T10:11:33Z-
dc.date.available2014-01-07T10:11:33Z-
dc.date.issued2013-
dc.identifier.citationSynthesis of the spiroketal core of integramycin. 2013, 9:2446-50 Beilstein J Org Chemen
dc.identifier.issn1860-5397-
dc.identifier.pmid24367411-
dc.identifier.doi10.3762/bjoc.9.282-
dc.identifier.urihttp://hdl.handle.net/10033/310994-
dc.description.abstractA concise synthetic strategy towards the spiroketal core of the HIV-integrase inhibitor integramycin (1) was developed. The required ketone precursor was efficiently constructed from two simple and easily accessible subunits by means of a hydrozirconation/copper catalyzed acylation reaction. The effects of different protecting groups on the spiroketalization step were also investigated.en
dc.language.isoenen
dc.rightsArchived with thanks to Beilstein journal of organic chemistryen
dc.titleSynthesis of the spiroketal core of integramycin.en
dc.typeArticleen
dc.contributor.departmentDepartment of Medicinal Chemistry, Helmholtz Centre for Infection Research, Inhoffenstr. 7, 38124 Braunschweig, Germanyen
dc.identifier.journalBeilstein journal of organic chemistryen
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