2.50
Hdl Handle:
http://hdl.handle.net/10033/311411
Title:
Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.
Authors:
Nandakumar, Ramya; Finsterbusch, Katja; Lipps, Christoph; Neumann, Berit; Grashoff, Martina; Nair, Sharmila; Hochnadel, Inga; Lienenklaus, Stefan; Wappler, Ilka; Steinmann, Eike; Hauser, Hansjörg; Pietschmann, Thomas; Kröger, Andrea ( 0000-0002-3131-6580 )
Abstract:
Current treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50% of patients control HCV infection after treatment, but the broad range of patients' outcomes and responses to treatment, among all genotypes, indicates a role for host factors. Although the IFN system is important in limiting HCV replication, the virus has evolved mechanisms to circumvent the IFN response. However, direct, IFN-independent antiviral processes also might help control HCV replication. We examined the role of IFN-independent responses against HCV replication.
Affiliation:
Helmholtz Centre for infection research, D38124 Braunschweig, Germany
Citation:
Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms. 2013, 145 (6):1414-23.e1 Gastroenterology
Journal:
Gastroenterology
Issue Date:
Dec-2013
URI:
http://hdl.handle.net/10033/311411
DOI:
10.1053/j.gastro.2013.08.037
PubMed ID:
23973921
Type:
Article
Language:
en
ISSN:
1528-0012
Appears in Collections:
publications of the research group intravital microscopy in infection and immunity (INMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorNandakumar, Ramyaen
dc.contributor.authorFinsterbusch, Katjaen
dc.contributor.authorLipps, Christophen
dc.contributor.authorNeumann, Beriten
dc.contributor.authorGrashoff, Martinaen
dc.contributor.authorNair, Sharmilaen
dc.contributor.authorHochnadel, Ingaen
dc.contributor.authorLienenklaus, Stefanen
dc.contributor.authorWappler, Ilkaen
dc.contributor.authorSteinmann, Eikeen
dc.contributor.authorHauser, Hansjörgen
dc.contributor.authorPietschmann, Thomasen
dc.contributor.authorKröger, Andreaen
dc.date.accessioned2014-01-16T15:27:18Zen
dc.date.available2014-01-16T15:27:18Zen
dc.date.issued2013-12en
dc.identifier.citationHepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms. 2013, 145 (6):1414-23.e1 Gastroenterologyen
dc.identifier.issn1528-0012en
dc.identifier.pmid23973921en
dc.identifier.doi10.1053/j.gastro.2013.08.037en
dc.identifier.urihttp://hdl.handle.net/10033/311411en
dc.description.abstractCurrent treatment strategies for hepatitis C virus (HCV) infection include pegylated interferon (IFN)-alfa and ribavirin. Approximately 50% of patients control HCV infection after treatment, but the broad range of patients' outcomes and responses to treatment, among all genotypes, indicates a role for host factors. Although the IFN system is important in limiting HCV replication, the virus has evolved mechanisms to circumvent the IFN response. However, direct, IFN-independent antiviral processes also might help control HCV replication. We examined the role of IFN-independent responses against HCV replication.en
dc.language.isoenen
dc.rightsArchived with thanks to Gastroenterologyen
dc.titleHepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, D38124 Braunschweig, Germanyen
dc.identifier.journalGastroenterologyen

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