Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.

2.50
Hdl Handle:
http://hdl.handle.net/10033/311421
Title:
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.
Authors:
Steinbach, Anke; Maurer, Christine K; Weidel, Elisabeth; Henn, Claudia; Brengel, Christian; Hartmann, Rolf W; Negri, Matthias
Abstract:
PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ.
Citation:
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies. 2013, 6 (1):10 BMC Biophys
Journal:
BMC biophysics
Issue Date:
2013
URI:
http://hdl.handle.net/10033/311421
DOI:
10.1186/2046-1682-6-10
PubMed ID:
23916145
Type:
Article
Language:
en
ISSN:
2046-1682
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorSteinbach, Ankeen
dc.contributor.authorMaurer, Christine Ken
dc.contributor.authorWeidel, Elisabethen
dc.contributor.authorHenn, Claudiaen
dc.contributor.authorBrengel, Christianen
dc.contributor.authorHartmann, Rolf Wen
dc.contributor.authorNegri, Matthiasen
dc.date.accessioned2014-01-16T14:53:04Zen
dc.date.available2014-01-16T14:53:04Zen
dc.date.issued2013en
dc.identifier.citationMolecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies. 2013, 6 (1):10 BMC Biophysen
dc.identifier.issn2046-1682en
dc.identifier.pmid23916145en
dc.identifier.doi10.1186/2046-1682-6-10en
dc.identifier.urihttp://hdl.handle.net/10033/311421en
dc.description.abstractPQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor PqsR that induces virulence factor production and biofilm formation. The enzyme PqsD catalyses the biosynthesis of HHQ.en
dc.language.isoenen
dc.rightsArchived with thanks to BMC biophysicsen
dc.titleMolecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies.en
dc.typeArticleen
dc.identifier.journalBMC biophysicsen

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