Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies.
Name:
Han and Kursula_final.pdf
Size:
945.9Kb
Format:
PDF
Description:
authorized electronic re-print
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2013-07
Metadata
Show full item recordAbstract
Periaxin (PRX) is an abundant protein in peripheral nerves and contains a predicted PDZ-like domain at its N-terminus. The large isoform, L-PRX, is required for the maintenance of myelin in the peripheral nervous system and its defects cause neurological disease. Here, the human periaxin PDZ-like domain was crystallized and X-ray diffraction data were collected to 2.85 Å resolution using synchrotron radiation. The crystal belonged to the primitive hexagonal space group P3121 or P3221, with unit-cell parameters a = b = 80.6, c = 81.0 Å, γ = 120° and either two or three molecules in the asymmetric unit. The structure of PRX will shed light on its poorly characterized function in the nervous system.Citation
Preliminary crystallographic analysis of the N-terminal PDZ-like domain of periaxin, an abundant peripheral nerve protein linked to human neuropathies. 2013, 69 (Pt 7):804-8 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.PubMed ID
23832213Type
ArticleLanguage
enISSN
1744-3091ae974a485f413a2113503eed53cd6c53
10.1107/S1744309113016266
Scopus Count
Collections
The following license files are associated with this item:
Related articles
- Periaxin and AHNAK nucleoprotein 2 form intertwined homodimers through domain swapping.
- Authors: Han H, Kursula P
- Issue date: 2014 May 16
- Nuclear export of L-periaxin, mediated by its nuclear export signal in the PDZ domain.
- Authors: Shi Y, Zhang L, Yang T
- Issue date: 2014
- Antibodies to L-periaxin in sera of patients with peripheral neuropathy produce experimental sensory nerve conduction deficits.
- Authors: Lawlor MW, Richards MP, De Vries GH, Fisher MA, Stubbs EB Jr
- Issue date: 2002 Nov
- Crystallization and preliminary X-ray crystallographic studies of the PDZ domain of Shank1 from Rattus norvegicus.
- Authors: Park SH, Im YJ, Rho SH, Lee JH, Yang S, Kim E, Eom SH
- Issue date: 2002 Aug
- Two PDZ domain proteins encoded by the murine periaxin gene are the result of alternative intron retention and are differentially targeted in Schwann cells.
- Authors: Dytrych L, Sherman DL, Gillespie CS, Brophy PJ
- Issue date: 1998 Mar 6