Multifunctional silica nanoparticles for optical and magnetic resonance imaging.

2.50
Hdl Handle:
http://hdl.handle.net/10033/316742
Title:
Multifunctional silica nanoparticles for optical and magnetic resonance imaging.
Authors:
Joshi, Rajendra; Feldmann, Verena; Koestner, Wolfgang; Detje, Claudia; Gottschalk, Sven; Mayer, Hermann A; Sauer, Martin G; Engelmann, Jörn
Abstract:
The surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.
Affiliation:
Institute for Experimental Infection Research, TWINCORE , Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Straβe 7, D-30625 Hannover, Germany
Citation:
Multifunctional silica nanoparticles for optical and magnetic resonance imaging. 2013, 394 (1):125-35 Biol. Chem.
Journal:
Biological chemistry
Issue Date:
Jan-2013
URI:
http://hdl.handle.net/10033/316742
DOI:
10.1515/hsz-2012-0251
PubMed ID:
23096570
Type:
Article
Language:
en
ISSN:
1437-4315
Appears in Collections:
Publications of the TwinCore unit experimental Infectionresearch(EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorJoshi, Rajendraen
dc.contributor.authorFeldmann, Verenaen
dc.contributor.authorKoestner, Wolfgangen
dc.contributor.authorDetje, Claudiaen
dc.contributor.authorGottschalk, Svenen
dc.contributor.authorMayer, Hermann Aen
dc.contributor.authorSauer, Martin Gen
dc.contributor.authorEngelmann, Jörnen
dc.date.accessioned2014-05-13T14:56:54Z-
dc.date.available2014-05-13T14:56:54Z-
dc.date.issued2013-01-
dc.identifier.citationMultifunctional silica nanoparticles for optical and magnetic resonance imaging. 2013, 394 (1):125-35 Biol. Chem.en
dc.identifier.issn1437-4315-
dc.identifier.pmid23096570-
dc.identifier.doi10.1515/hsz-2012-0251-
dc.identifier.urihttp://hdl.handle.net/10033/316742-
dc.description.abstractThe surface of spherical, nonporous silica nanoparticles (SiO2-NPs) was modified with gadolinium (Gd) complexes, fluorophores, and cell-penetrating peptides to achieve multifunctionality on a single particle. The Gd surface concentrations were 9-16 μmol/g resulting in nanomaterials with high local longitudinal and transversal relaxivities (~1×10(5) and ~5×10(5) /mm/s/NP, respectively). Rapid cellular uptake was observed in vitro; however, larger extracellular agglomerates were also formed. In vivo administration revealed a fast distribution throughout the body followed by a nearly complete disappearance of fluorescence in all organs except the lungs, liver, and spleen after 24 h. Such NPs have the potential to serve as efficient multimodal probes in molecular imaging.en
dc.language.isoenen
dc.rightsArchived with thanks to Biological chemistryen
dc.titleMultifunctional silica nanoparticles for optical and magnetic resonance imaging.en
dc.typeArticleen
dc.contributor.departmentInstitute for Experimental Infection Research, TWINCORE , Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Straβe 7, D-30625 Hannover, Germanyen
dc.identifier.journalBiological chemistryen

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