Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/323806
Title:
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.
Authors:
Weiss, Jonathan M; Bilate, Angelina M; Gobert, Michael; Ding, Yi; Curotto de Lafaille, Maria A; Parkhurst, Christopher N; Xiong, Huizhong; Dolpady, Jayashree; Frey, Alan B; Ruocco, Maria Grazia; Yang, Yi; Floess, Stefan; Huehn, Jochen; Oh, Soyoung; Li, Ming O; Niec, Rachel E; Rudensky, Alexander Y; Dustin, Michael L; Littman, Dan R; Lafaille, Juan J
Abstract:
Foxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease.
Citation:
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. 2012, 209 (10):1723-42, S1 J. Exp. Med.
Journal:
The Journal of experimental medicine
Issue Date:
24-Sep-2012
URI:
http://hdl.handle.net/10033/323806
DOI:
10.1084/jem.20120914
PubMed ID:
22966001
Type:
Article
Language:
en
ISSN:
1540-9538
Appears in Collections:
publications of the division experimentelle Immunologie (EXIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorWeiss, Jonathan Men
dc.contributor.authorBilate, Angelina Men
dc.contributor.authorGobert, Michaelen
dc.contributor.authorDing, Yien
dc.contributor.authorCurotto de Lafaille, Maria Aen
dc.contributor.authorParkhurst, Christopher Nen
dc.contributor.authorXiong, Huizhongen
dc.contributor.authorDolpady, Jayashreeen
dc.contributor.authorFrey, Alan Ben
dc.contributor.authorRuocco, Maria Graziaen
dc.contributor.authorYang, Yien
dc.contributor.authorFloess, Stefanen
dc.contributor.authorHuehn, Jochenen
dc.contributor.authorOh, Soyoungen
dc.contributor.authorLi, Ming Oen
dc.contributor.authorNiec, Rachel Een
dc.contributor.authorRudensky, Alexander Yen
dc.contributor.authorDustin, Michael Len
dc.contributor.authorLittman, Dan Ren
dc.contributor.authorLafaille, Juan Jen
dc.date.accessioned2014-07-25T09:24:02Z-
dc.date.available2014-07-25T09:24:02Z-
dc.date.issued2012-09-24-
dc.identifier.citationNeuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. 2012, 209 (10):1723-42, S1 J. Exp. Med.en
dc.identifier.issn1540-9538-
dc.identifier.pmid22966001-
dc.identifier.doi10.1084/jem.20120914-
dc.identifier.urihttp://hdl.handle.net/10033/323806-
dc.description.abstractFoxp3 activity is essential for the normal function of the immune system. Two types of regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and peripherally generated adaptive T reg (iT reg) cells. These cell types have complementary functions. Until now, it has not been possible to distinguish iT reg from nT reg cells in vivo based solely on surface markers. We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most nT reg cells; in contrast, mucosa-generated iT reg and other noninflammatory iT reg cells express low levels of Nrp1. We found that Nrp1 expression is under the control of TGF-β. By tracing nT reg and iT reg cells, we could establish that some tumors have a very large proportion of infiltrating iT reg cells. iT reg cells obtained from highly inflammatory environments, such as the spinal cords of mice with spontaneous autoimmune encephalomyelitis (EAE) and the lungs of mice with chronic asthma, express Nrp1. In the same animals, iT reg cells in secondary lymphoid organs remain Nrp1(low). We also determined that, in spontaneous EAE, iT reg cells help to establish a chronic phase of the disease.en
dc.language.isoenen
dc.rightsArchived with thanks to The Journal of experimental medicineen
dc.subject.meshAnimalsen
dc.subject.meshCell Lineageen
dc.subject.meshCell Membraneen
dc.subject.meshForkhead Transcription Factorsen
dc.subject.meshGene Expression Regulationen
dc.subject.meshInflammationen
dc.subject.meshIntestinesen
dc.subject.meshLymphocyte Activationen
dc.subject.meshLymphocytes, Tumor-Infiltratingen
dc.subject.meshMetagenomeen
dc.subject.meshMiceen
dc.subject.meshMice, Transgenicen
dc.subject.meshMucous Membraneen
dc.subject.meshNeuropilin-1en
dc.subject.meshT-Lymphocytes, Regulatoryen
dc.subject.meshThymus Glanden
dc.subject.meshTransforming Growth Factor betaen
dc.titleNeuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells.en
dc.typeArticleen
dc.identifier.journalThe Journal of experimental medicineen

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