5.00
Hdl Handle:
http://hdl.handle.net/10033/324125
Title:
Hypoxyvermelhotins A-C, new pigments from Hypoxylon lechatii sp. nov.
Authors:
Kuhnert, Eric; Heitkämper, Simone; Fournier, Jacques; Surup, Frank; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
A new species of Hypoxylon was discovered, based on material collected in French Guiana and recognised on the basis of new combination of morpholological characters in comparison with type and authentic material of macroscopically similar taxa. These findings were corroborated by the rather isolated positions of its ITS-nrDNA and beta-tubulin DNA sequences in molecular phylogenies. However, the most salient feature of this fungus only became evident by a comparison of its stromatal HPLC profile, revealing several secondary metabolites that were hitherto not observed in stromata of any other member of the Xylariaceae. Part of the stromata were subsequently extracted to isolate these apparently specific components, using preparative chromatography. Five metabolites were obtained in pure state, and their chemical structures were elucidated by means of high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. They turned out to be tetramic acid derivatives of the so-called vermelhotin type. Aside from vermelhotin, previously isolated from cultures of endophytic fungi, we identified three novel congeners, for which the trivial names hypoxyvermelhotins A-C were proposed. Like vermelhotin, they constitute orange-red pigments and a preliminary biological characterisation revealed them to have rather strong cytotoxic and moderate to weak antimicrobial effects. These results further illustrate the high diversity of unique secondary metabolites in stromata of the hypoxyloid Xylariaceae, a family in which biological diversity seems to parallel the chemical diversity of their bioactive principles to a great extent.
Affiliation:
Dept of microbial drugs, Helmholtz-Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Hypoxyvermelhotins A-C, new pigments from Hypoxylon lechatii sp. nov. 2014, 118 (2):242-52 Fungal Biol
Journal:
Fungal biology
Issue Date:
Feb-2014
URI:
http://hdl.handle.net/10033/324125
DOI:
10.1016/j.funbio.2013.12.003
PubMed ID:
24528645
Type:
Article
Language:
en
ISSN:
1878-6146
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorKuhnert, Ericen
dc.contributor.authorHeitkämper, Simoneen
dc.contributor.authorFournier, Jacquesen
dc.contributor.authorSurup, Franken
dc.contributor.authorStadler, Marcen
dc.date.accessioned2014-08-04T13:32:37Zen
dc.date.available2014-08-04T13:32:37Zen
dc.date.issued2014-02en
dc.identifier.citationHypoxyvermelhotins A-C, new pigments from Hypoxylon lechatii sp. nov. 2014, 118 (2):242-52 Fungal Biolen
dc.identifier.issn1878-6146en
dc.identifier.pmid24528645en
dc.identifier.doi10.1016/j.funbio.2013.12.003en
dc.identifier.urihttp://hdl.handle.net/10033/324125en
dc.description.abstractA new species of Hypoxylon was discovered, based on material collected in French Guiana and recognised on the basis of new combination of morpholological characters in comparison with type and authentic material of macroscopically similar taxa. These findings were corroborated by the rather isolated positions of its ITS-nrDNA and beta-tubulin DNA sequences in molecular phylogenies. However, the most salient feature of this fungus only became evident by a comparison of its stromatal HPLC profile, revealing several secondary metabolites that were hitherto not observed in stromata of any other member of the Xylariaceae. Part of the stromata were subsequently extracted to isolate these apparently specific components, using preparative chromatography. Five metabolites were obtained in pure state, and their chemical structures were elucidated by means of high resolution mass spectrometry and nuclear magnetic resonance spectroscopy. They turned out to be tetramic acid derivatives of the so-called vermelhotin type. Aside from vermelhotin, previously isolated from cultures of endophytic fungi, we identified three novel congeners, for which the trivial names hypoxyvermelhotins A-C were proposed. Like vermelhotin, they constitute orange-red pigments and a preliminary biological characterisation revealed them to have rather strong cytotoxic and moderate to weak antimicrobial effects. These results further illustrate the high diversity of unique secondary metabolites in stromata of the hypoxyloid Xylariaceae, a family in which biological diversity seems to parallel the chemical diversity of their bioactive principles to a great extent.en
dc.language.isoenen
dc.rightsArchived with thanks to Fungal biologyen
dc.titleHypoxyvermelhotins A-C, new pigments from Hypoxylon lechatii sp. nov.en
dc.typeArticleen
dc.contributor.departmentDept of microbial drugs, Helmholtz-Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalFungal biologyen

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