Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.

2.50
Hdl Handle:
http://hdl.handle.net/10033/324347
Title:
Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.
Authors:
Fang, Kechi; Zhao, Hansheng; Sun, Changyue; Lam, Carolyn M C; Chang, Suhua; Zhang, Kunlin; Panda, Gurudutta; Godinho, Miguel; Martins dos Santos, Vítor A P; Wang, Jing
Abstract:
Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.
Citation:
Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. 2011, 5:83 BMC Syst Biol
Journal:
BMC systems biology
Issue Date:
2011
URI:
http://hdl.handle.net/10033/324347
DOI:
10.1186/1752-0509-5-83
PubMed ID:
21609491
Type:
Article
Language:
en
ISSN:
1752-0509
Appears in Collections:
Publications of the RG Systems and synthetic biology (SSBI)

Full metadata record

DC FieldValue Language
dc.contributor.authorFang, Kechien
dc.contributor.authorZhao, Hanshengen
dc.contributor.authorSun, Changyueen
dc.contributor.authorLam, Carolyn M Cen
dc.contributor.authorChang, Suhuaen
dc.contributor.authorZhang, Kunlinen
dc.contributor.authorPanda, Guruduttaen
dc.contributor.authorGodinho, Miguelen
dc.contributor.authorMartins dos Santos, Vítor A Pen
dc.contributor.authorWang, Jingen
dc.date.accessioned2014-08-07T13:05:02Z-
dc.date.available2014-08-07T13:05:02Z-
dc.date.issued2011-
dc.identifier.citationExploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction. 2011, 5:83 BMC Syst Biolen
dc.identifier.issn1752-0509-
dc.identifier.pmid21609491-
dc.identifier.doi10.1186/1752-0509-5-83-
dc.identifier.urihttp://hdl.handle.net/10033/324347-
dc.description.abstractBurkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection. Strain B. cenocepacia J2315 is the most infectious isolate from CF patients. There is a strong demand to reconstruct a genome-scale metabolic network of B. cenocepacia J2315 to systematically analyze its metabolic capabilities and its virulence traits, and to search for potential clinical therapy targets.en
dc.language.isoenen
dc.rightsArchived with thanks to BMC systems biologyen
dc.subject.meshAnti-Bacterial Agentsen
dc.subject.meshBiomassen
dc.subject.meshBurkholderia Infectionsen
dc.subject.meshBurkholderia cenocepaciaen
dc.subject.meshCatalysisen
dc.subject.meshComputational Biologyen
dc.subject.meshDrug Resistance, Bacterialen
dc.subject.meshFatty Acidsen
dc.subject.meshGenomeen
dc.subject.meshGenome, Bacterialen
dc.subject.meshHumansen
dc.subject.meshLipopolysaccharidesen
dc.subject.meshModels, Biologicalen
dc.subject.meshModels, Statisticalen
dc.subject.meshPhenotypeen
dc.subject.meshSystems Biologyen
dc.titleExploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction.en
dc.typeArticleen
dc.identifier.journalBMC systems biologyen

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