Influence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium.
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Issue Date
2011-06
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Show full item recordAbstract
Administration of facultative anaerobic bacteria such as Salmonella enterica serovar Typhimurium as anticancer treatment holds a great therapeutic potential. Here, we tested different routes of application of S. typhimurium with regard to tumor colonization and therapeutic efficacy. No differences between intravenous and intraperitoneal infection were observed, often leading to a complete tumor clearance. In contrast, after oral application, tumor colonization was inefficient and delayed. No therapeutic effect was observed under such conditions. We also showed that tumor invasion and colonization were independent of functional Salmonella pathogenicity island (SPI) 1 and SPI 2. Furthermore, tumor invasion and colonization did not require bacterial motility or chemotactic responsiveness. The distribution of the bacteria within the tumor was independent of such functions.Citation
Influence of infection route and virulence factors on colonization of solid tumors by Salmonella enterica serovar Typhimurium. 2011, 62 (1):75-83 FEMS Immunol. Med. Microbiol.Affiliation
Dept. Molecular Immunology, Helmholtz Centre for infection research, Inhoffenstr. 7, D38124 Braunschweig, Germany.PubMed ID
21314734Type
ArticleLanguage
enISSN
1574-695Xae974a485f413a2113503eed53cd6c53
10.1111/j.1574-695X.2011.00790.x
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