E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/325170
Title:
E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.
Authors:
Straub, Beate K; Rickelt, Steffen; Zimbelmann, Ralf; Grund, Christine; Kuhn, Caecilia; Iken, Marcus; Ott, Michael; Schirmacher, Peter; Franke, Werner W
Abstract:
Intercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this "cadherin switch" hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.
Citation:
E-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. 2011, 195 (5):873-87 J. Cell Biol.
Journal:
The Journal of cell biology
Issue Date:
28-Nov-2011
URI:
http://hdl.handle.net/10033/325170
DOI:
10.1083/jcb.201106023
PubMed ID:
22105347
Type:
Article
Language:
en
ISSN:
1540-8140
Appears in Collections:
publications of the AG cell and gene therapy

Full metadata record

DC FieldValue Language
dc.contributor.authorStraub, Beate Ken
dc.contributor.authorRickelt, Steffenen
dc.contributor.authorZimbelmann, Ralfen
dc.contributor.authorGrund, Christineen
dc.contributor.authorKuhn, Caeciliaen
dc.contributor.authorIken, Marcusen
dc.contributor.authorOtt, Michaelen
dc.contributor.authorSchirmacher, Peteren
dc.contributor.authorFranke, Werner Wen
dc.date.accessioned2014-08-25T13:08:29Z-
dc.date.available2014-08-25T13:08:29Z-
dc.date.issued2011-11-28-
dc.identifier.citationE-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells. 2011, 195 (5):873-87 J. Cell Biol.en
dc.identifier.issn1540-8140-
dc.identifier.pmid22105347-
dc.identifier.doi10.1083/jcb.201106023-
dc.identifier.urihttp://hdl.handle.net/10033/325170-
dc.description.abstractIntercellular junctions play a pivotal role in tissue development and function and also in tumorigenesis. In epithelial cells, decrease or loss of E-cadherin, the hallmark molecule of adherens junctions (AJs), and increase of N-cadherin are widely thought to promote carcinoma progression and metastasis. In this paper, we show that this "cadherin switch" hypothesis does not hold for diverse endoderm-derived cells and cells of tumors derived from them. We show that the cadherins in a major portion of AJs in these cells can be chemically cross-linked in E-N heterodimers. We also show that cells possessing E-N heterodimer AJs can form semistable hemihomotypic AJs with purely N-cadherin-based AJs of mesenchymally derived cells, including stroma cells. We conclude that these heterodimers are the major AJ constituents of several endoderm-derived tissues and tumors and that the prevailing concept of antagonistic roles of these two cadherins in developmental and tumor biology has to be reconsidered.en
dc.language.isoenen
dc.rightsArchived with thanks to The Journal of cell biologyen
dc.subject.meshAdherens Junctionsen
dc.subject.meshAnimalsen
dc.subject.meshCadherinsen
dc.subject.meshCattleen
dc.subject.meshCell Adhesionen
dc.subject.meshEndodermen
dc.subject.meshHumansen
dc.subject.meshMiceen
dc.subject.meshRatsen
dc.subject.meshSwineen
dc.subject.meshTumor Cells, Cultureden
dc.titleE-N-cadherin heterodimers define novel adherens junctions connecting endoderm-derived cells.en
dc.typeArticleen
dc.identifier.journalThe Journal of cell biologyen

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