Bactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus.

2.50
Hdl Handle:
http://hdl.handle.net/10033/326050
Title:
Bactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus.
Authors:
Cartron, Michaël L; England, Simon R; Chiriac, Alina Iulia; Josten, Michaele; Turner, Robert; Rauter, Yvonne; Hurd, Alexander; Sahl, Hans-Georg; Jones, Simon; Foster, Simon J
Abstract:
Human skin fatty acids are a potent aspect of our innate defenses, giving surface protection against potentially invasive organisms. They provide an important parameter in determining the ecology of the skin microflora, and alterations can lead to increased colonization by pathogens such as Staphylococcus aureus. Harnessing skin fatty acids may also give a new avenue of exploration in the generation of control measures against drug-resistant organisms. Despite their importance, the mechanism(s) whereby skin fatty acids kill bacteria has remained largely elusive. Here, we describe an analysis of the bactericidal effects of the major human skin fatty acid cis-6-hexadecenoic acid (C6H) on the human commensal and pathogen S. aureus. Several C6H concentration-dependent mechanisms were found. At high concentrations, C6H swiftly kills cells associated with a general loss of membrane integrity. However, C6H still kills at lower concentrations, acting through disruption of the proton motive force, an increase in membrane fluidity, and its effects on electron transfer. The design of analogues with altered bactericidal effects has begun to determine the structural constraints on activity and paves the way for the rational design of new antistaphylococcal agents.
Citation:
Bactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus. 2014, 58 (7):3599-609 Antimicrob. Agents Chemother.
Journal:
Antimicrobial agents and chemotherapy
Issue Date:
Jul-2014
URI:
http://hdl.handle.net/10033/326050
DOI:
10.1128/AAC.01043-13
PubMed ID:
24709265
Type:
Article
Language:
en
ISSN:
1098-6596
Appears in Collections:
publications of the AG system-oriented immunologyand infection research (SIME)

Full metadata record

DC FieldValue Language
dc.contributor.authorCartron, Michaël Len
dc.contributor.authorEngland, Simon Ren
dc.contributor.authorChiriac, Alina Iuliaen
dc.contributor.authorJosten, Michaeleen
dc.contributor.authorTurner, Roberten
dc.contributor.authorRauter, Yvonneen
dc.contributor.authorHurd, Alexanderen
dc.contributor.authorSahl, Hans-Georgen
dc.contributor.authorJones, Simonen
dc.contributor.authorFoster, Simon Jen
dc.date.accessioned2014-09-10T14:56:54Z-
dc.date.available2014-09-10T14:56:54Z-
dc.date.issued2014-07-
dc.identifier.citationBactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus. 2014, 58 (7):3599-609 Antimicrob. Agents Chemother.en
dc.identifier.issn1098-6596-
dc.identifier.pmid24709265-
dc.identifier.doi10.1128/AAC.01043-13-
dc.identifier.urihttp://hdl.handle.net/10033/326050-
dc.description.abstractHuman skin fatty acids are a potent aspect of our innate defenses, giving surface protection against potentially invasive organisms. They provide an important parameter in determining the ecology of the skin microflora, and alterations can lead to increased colonization by pathogens such as Staphylococcus aureus. Harnessing skin fatty acids may also give a new avenue of exploration in the generation of control measures against drug-resistant organisms. Despite their importance, the mechanism(s) whereby skin fatty acids kill bacteria has remained largely elusive. Here, we describe an analysis of the bactericidal effects of the major human skin fatty acid cis-6-hexadecenoic acid (C6H) on the human commensal and pathogen S. aureus. Several C6H concentration-dependent mechanisms were found. At high concentrations, C6H swiftly kills cells associated with a general loss of membrane integrity. However, C6H still kills at lower concentrations, acting through disruption of the proton motive force, an increase in membrane fluidity, and its effects on electron transfer. The design of analogues with altered bactericidal effects has begun to determine the structural constraints on activity and paves the way for the rational design of new antistaphylococcal agents.en
dc.language.isoenen
dc.rightsArchived with thanks to Antimicrobial agents and chemotherapyen
dc.titleBactericidal Activity of the Human Skin Fatty Acid cis-6-Hexadecanoic Acid on Staphylococcus aureus.en
dc.typeArticleen
dc.identifier.journalAntimicrobial agents and chemotherapyen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.