New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.

2.50
Hdl Handle:
http://hdl.handle.net/10033/326174
Title:
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.
Authors:
Zhu, Weixing; Haupenthal, Jörg; Groh, Matthias; Fountain, Michelle; Hartmann, Rolf W
Abstract:
CBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.
Citation:
New insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother.
Journal:
Antimicrobial agents and chemotherapy
Issue Date:
Jul-2014
URI:
http://hdl.handle.net/10033/326174
DOI:
10.1128/AAC.02600-14
PubMed ID:
24820077
Type:
Article
Language:
en
ISSN:
1098-6596
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorZhu, Weixingen
dc.contributor.authorHaupenthal, Jörgen
dc.contributor.authorGroh, Matthiasen
dc.contributor.authorFountain, Michelleen
dc.contributor.authorHartmann, Rolf Wen
dc.date.accessioned2014-09-16T12:41:07Z-
dc.date.available2014-09-16T12:41:07Z-
dc.date.issued2014-07-
dc.identifier.citationNew insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent. 2014, 58 (7):4242-5 Antimicrob. Agents Chemother.en
dc.identifier.issn1098-6596-
dc.identifier.pmid24820077-
dc.identifier.doi10.1128/AAC.02600-14-
dc.identifier.urihttp://hdl.handle.net/10033/326174-
dc.description.abstractCBR703 was reported to inhibit bacterial RNA polymerase (RNAP) and biofilm formation, considering it to be a good candidate for further optimization. While synthesized derivatives of CBR703 did not result in more-active RNAP inhibitors, we observed promising antibacterial activities. These again correlated with a significant cytotoxicity toward mammalian cells. Furthermore, we suspect the promising effects on biofilm formation to be artifacts. Consequently, this class of compounds can be considered unattractive as antibacterial agents.en
dc.language.isoenen
dc.rightsArchived with thanks to Antimicrobial agents and chemotherapyen
dc.titleNew insights into the bacterial RNA polymerase inhibitor CBR703 as a starting point for optimization as an anti-infective agent.en
dc.typeArticleen
dc.identifier.journalAntimicrobial agents and chemotherapyen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.