2.50
Hdl Handle:
http://hdl.handle.net/10033/332351
Title:
Cellular changes in blood indicate severe respiratory disease during influenza infections in mice.
Authors:
Dengler, Leonie; Kühn, Nora; Shin, Dai-Lun; Hatesuer, Bastian; Schughart, Klaus ( 0000-0002-6824-7523 ) ; Wilk, Esther ( 0000-0003-3446-5511 )
Abstract:
Influenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mouse is a valuable model system enabling us to study the local inflammatory host response and the influence on blood parameters under controlled circumstances. Here, we compared the lung and peripheral changes after PR8 (H1N1) influenza A virus infection in C57BL/6J and DBA/2J mice using virus variants of different pathogenicity resulting in non-lethal and lethal disease. We monitored hematological and immunological parameters revealing that the granulocyte to lymphocyte ratio in the blood represents an early indicator of severe disease progression already two days after influenza A infection in mice. These findings might be relevant to optimize early diagnostic options of severe influenza disease and to monitor successful therapeutic treatment in humans.
Citation:
Cellular changes in blood indicate severe respiratory disease during influenza infections in mice. 2014, 9 (7):e103149 PLoS ONE
Journal:
PloS one
Issue Date:
2014
URI:
http://hdl.handle.net/10033/332351
DOI:
10.1371/journal.pone.0103149
PubMed ID:
25058639
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorDengler, Leonieen
dc.contributor.authorKühn, Noraen
dc.contributor.authorShin, Dai-Lunen
dc.contributor.authorHatesuer, Bastianen
dc.contributor.authorSchughart, Klausen
dc.contributor.authorWilk, Estheren
dc.date.accessioned2014-10-09T08:55:44Zen
dc.date.available2014-10-09T08:55:44Zen
dc.date.issued2014en
dc.identifier.citationCellular changes in blood indicate severe respiratory disease during influenza infections in mice. 2014, 9 (7):e103149 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid25058639en
dc.identifier.doi10.1371/journal.pone.0103149en
dc.identifier.urihttp://hdl.handle.net/10033/332351en
dc.description.abstractInfluenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mouse is a valuable model system enabling us to study the local inflammatory host response and the influence on blood parameters under controlled circumstances. Here, we compared the lung and peripheral changes after PR8 (H1N1) influenza A virus infection in C57BL/6J and DBA/2J mice using virus variants of different pathogenicity resulting in non-lethal and lethal disease. We monitored hematological and immunological parameters revealing that the granulocyte to lymphocyte ratio in the blood represents an early indicator of severe disease progression already two days after influenza A infection in mice. These findings might be relevant to optimize early diagnostic options of severe influenza disease and to monitor successful therapeutic treatment in humans.en
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen
dc.titleCellular changes in blood indicate severe respiratory disease during influenza infections in mice.en
dc.typeArticleen
dc.identifier.journalPloS oneen

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