In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways.

2.50
Hdl Handle:
http://hdl.handle.net/10033/338661
Title:
In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways.
Authors:
Goikoetxea, Estibalitz; Murgia, Xabier; Serna-Grande, Pablo; Valls-i-Soler, Adolf; Rey-Santano, Carmen; Rivas, Alejandro; Antón, Raúl; Basterretxea, Francisco J; Miñambres, Lorena; Méndez, Estíbaliz; Lopez-Arraiza, Alberto; Larrabe-Barrena, Juan Luis; Gomez-Solaetxe, Miguel Angel
Abstract:
Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in neonates tends to be very low due to extremely low lung volumes, narrow airways and high respiratory rates. In the present study, the feasibility of enhancing lung deposition by intracorporeal delivery of aerosols was investigated using a physical model of neonatal conducting airways.
Citation:
In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways. 2014, 9 (9):e106835 PLoS ONE
Journal:
PloS one
Issue Date:
2014
URI:
http://hdl.handle.net/10033/338661
DOI:
10.1371/journal.pone.0106835
PubMed ID:
25211475
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorGoikoetxea, Estibalitzen
dc.contributor.authorMurgia, Xabieren
dc.contributor.authorSerna-Grande, Pabloen
dc.contributor.authorValls-i-Soler, Adolfen
dc.contributor.authorRey-Santano, Carmenen
dc.contributor.authorRivas, Alejandroen
dc.contributor.authorAntón, Raúlen
dc.contributor.authorBasterretxea, Francisco Jen
dc.contributor.authorMiñambres, Lorenaen
dc.contributor.authorMéndez, Estíbalizen
dc.contributor.authorLopez-Arraiza, Albertoen
dc.contributor.authorLarrabe-Barrena, Juan Luisen
dc.contributor.authorGomez-Solaetxe, Miguel Angelen
dc.date.accessioned2015-01-22T10:46:25Z-
dc.date.available2015-01-22T10:46:25Z-
dc.date.issued2014-
dc.identifier.citationIn vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways. 2014, 9 (9):e106835 PLoS ONEen
dc.identifier.issn1932-6203-
dc.identifier.pmid25211475-
dc.identifier.doi10.1371/journal.pone.0106835-
dc.identifier.urihttp://hdl.handle.net/10033/338661-
dc.description.abstractAerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in neonates tends to be very low due to extremely low lung volumes, narrow airways and high respiratory rates. In the present study, the feasibility of enhancing lung deposition by intracorporeal delivery of aerosols was investigated using a physical model of neonatal conducting airways.en
dc.language.isoenen
dc.titleIn vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways.en
dc.typeArticleen
dc.identifier.journalPloS oneen

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