2.50
Hdl Handle:
http://hdl.handle.net/10033/339038
Title:
Host strategies against virus entry via the olfactory system.
Authors:
Kalinke, Ulrich ( 0000-0003-0503-9564 ) ; Bechmann, Ingo; Detje, Claudia N
Abstract:
In mammals, odorants are inhaled through the nose and inside the nasal cavity they trigger olfactory sensory neurons (OSN)  that are located within the olfactory epithelium. OSN project their axons into glomerular structures of the olfactory bulb. There they synapse with dendrites of second-order neurons that project their axons to the olfactory cortex. Thus, olfaction is based on direct interaction of environmental matters with OSN. This poses the question of how neurotropic viruses are prevented from infecting OSN and entering the central nervous system. Recent evidence indicates that upon instillation of neurotropic virus OSN are readily infected. By axonal transport virus reaches the glomerular  layer of the olfactory bulb where it is efficiently curbed by a type I IFN dependent mechanism. In this review local mechanisms limiting virus entry via the olfactory system and virus spread within the CNS are recapitulated in the context of anatomical properties of the olfactory system.
Citation:
Host strategies against virus entry via the olfactory system., 2 (4):367-70 Virulence
Journal:
Virulence
Issue Date:
29-Jan-2015
URI:
http://hdl.handle.net/10033/339038
PubMed ID:
21758005
Type:
Article
Language:
en
ISSN:
2150-5608
Appears in Collections:
publications of the department of experimental infection research ([TC] EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorKalinke, Ulrichen
dc.contributor.authorBechmann, Ingoen
dc.contributor.authorDetje, Claudia Nen
dc.date.accessioned2015-01-29T12:57:45Zen
dc.date.available2015-01-29T12:57:45Zen
dc.date.issued2015-01-29en
dc.identifier.citationHost strategies against virus entry via the olfactory system., 2 (4):367-70 Virulenceen
dc.identifier.issn2150-5608en
dc.identifier.pmid21758005en
dc.identifier.urihttp://hdl.handle.net/10033/339038en
dc.description.abstractIn mammals, odorants are inhaled through the nose and inside the nasal cavity they trigger olfactory sensory neurons (OSN)  that are located within the olfactory epithelium. OSN project their axons into glomerular structures of the olfactory bulb. There they synapse with dendrites of second-order neurons that project their axons to the olfactory cortex. Thus, olfaction is based on direct interaction of environmental matters with OSN. This poses the question of how neurotropic viruses are prevented from infecting OSN and entering the central nervous system. Recent evidence indicates that upon instillation of neurotropic virus OSN are readily infected. By axonal transport virus reaches the glomerular  layer of the olfactory bulb where it is efficiently curbed by a type I IFN dependent mechanism. In this review local mechanisms limiting virus entry via the olfactory system and virus spread within the CNS are recapitulated in the context of anatomical properties of the olfactory system.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshCentral Nervous Systemen
dc.subject.meshHost-Pathogen Interactionsen
dc.subject.meshHumansen
dc.subject.meshInterferon Type Ien
dc.subject.meshOlfactory Bulben
dc.subject.meshOlfactory Nerve Diseasesen
dc.subject.meshSensory Receptor Cellsen
dc.subject.meshVirus Internalizationen
dc.subject.meshVirus Physiological Phenomenaen
dc.titleHost strategies against virus entry via the olfactory system.en
dc.typeArticleen
dc.identifier.journalVirulenceen
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