Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

2.50
Hdl Handle:
http://hdl.handle.net/10033/345823
Title:
Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?
Authors:
Weidel, Elisabeth; Negri, Matthias; Empting, Martin; Hinsberger, Stefan; Hartmann, Rolf W
Abstract:
In order to identify new scaffolds for drug discovery, surface plasmon resonance is frequently used to screen structurally diverse libraries. Usually, hit rates are low and identification processes are time consuming. Hence, approaches which improve hit rates and, thus, reduce the library size are required.
Citation:
Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity? 2014, 6 (18):2057-72 Future Med Chem
Journal:
Future medicinal chemistry
Issue Date:
2014
URI:
http://hdl.handle.net/10033/345823
DOI:
10.4155/fmc.14.142
PubMed ID:
25531968
Type:
Article
Language:
en
ISSN:
1756-8927
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorWeidel, Elisabethen
dc.contributor.authorNegri, Matthiasen
dc.contributor.authorEmpting, Martinen
dc.contributor.authorHinsberger, Stefanen
dc.contributor.authorHartmann, Rolf Wen
dc.date.accessioned2015-03-02T13:39:14Zen
dc.date.available2015-03-02T13:39:14Zen
dc.date.issued2014en
dc.identifier.citationComposing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity? 2014, 6 (18):2057-72 Future Med Chemen
dc.identifier.issn1756-8927en
dc.identifier.pmid25531968en
dc.identifier.doi10.4155/fmc.14.142en
dc.identifier.urihttp://hdl.handle.net/10033/345823en
dc.description.abstractIn order to identify new scaffolds for drug discovery, surface plasmon resonance is frequently used to screen structurally diverse libraries. Usually, hit rates are low and identification processes are time consuming. Hence, approaches which improve hit rates and, thus, reduce the library size are required.en
dc.language.isoenen
dc.titleComposing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?en
dc.typeArticleen
dc.identifier.journalFuture medicinal chemistryen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.