Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study.

2.50
Hdl Handle:
http://hdl.handle.net/10033/346873
Title:
Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study.
Authors:
Maier, Ilko L; Karch, André ( 0000-0003-3014-8543 ) ; Mikolajczyk, Rafael ( 0000-0003-1271-7204 ) ; Bähr, Mathias; Liman, Jan
Abstract:
Infections are a frequent cause for prolonged hospitalization and increased mortality after stroke. Recent studies revealed a stroke-induced depression of the peripheral immune system associated with an increased susceptibility for infections. In a mice model for stroke, this immunosuppressive effect was reversible after beta-blocker administration. The aim of our study was to investigate the effect of beta-blocker therapy on the risk of infections and death after stroke in humans.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study. 2015, 10 (2):e0116836 PLoS ONE
Journal:
PloS one
Issue Date:
2015
URI:
http://hdl.handle.net/10033/346873
DOI:
10.1371/journal.pone.0116836
PubMed ID:
25643360
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
Publications of the AG (ESME)

Full metadata record

DC FieldValue Language
dc.contributor.authorMaier, Ilko Len
dc.contributor.authorKarch, Andréen
dc.contributor.authorMikolajczyk, Rafaelen
dc.contributor.authorBähr, Mathiasen
dc.contributor.authorLiman, Janen
dc.date.accessioned2015-03-19T13:02:11Zen
dc.date.available2015-03-19T13:02:11Zen
dc.date.issued2015en
dc.identifier.citationEffect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study. 2015, 10 (2):e0116836 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid25643360en
dc.identifier.doi10.1371/journal.pone.0116836en
dc.identifier.urihttp://hdl.handle.net/10033/346873en
dc.description.abstractInfections are a frequent cause for prolonged hospitalization and increased mortality after stroke. Recent studies revealed a stroke-induced depression of the peripheral immune system associated with an increased susceptibility for infections. In a mice model for stroke, this immunosuppressive effect was reversible after beta-blocker administration. The aim of our study was to investigate the effect of beta-blocker therapy on the risk of infections and death after stroke in humans.en
dc.language.isoenen
dc.titleEffect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalPloS oneen

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