The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.

2.50
Hdl Handle:
http://hdl.handle.net/10033/42254
Title:
The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.
Authors:
Gross, Roy; Guzman, Carlos A; Sebaihia, Mohammed; dos Santos, Vítor A P Martins; Pieper, Dietmar H; Koebnik, Ralf; Lechner, Melanie; Bartels, Daniela; Buhrmester, Jens; Choudhuri, Jomuna V; Ebensen, Thomas ( 0000-0001-8906-063X ) ; Gaigalat, Lars; Herrmann, Stefanie; Khachane, Amit N; Larisch, Christof; Link, Stefanie; Linke, Burkhard; Meyer, Folker; Mormann, Sascha; Nakunst, Diana; Rückert, Christian; Schneiker-Bekel, Susanne; Schulze, Kai ( 0000-0003-2286-3416 ) ; Vorhölter, Frank-Jörg; Yevsa, Tetyana; Engle, Jacquelyn T; Goldman, William E; Pühler, Alfred; Göbel, Ulf B; Goesmann, Alexander; Blöcker, Helmut; Kaiser, Olaf; Martinez-Arias, Rosa
Abstract:
BACKGROUND: Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. RESULTS: In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. CONCLUSION: The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.
Affiliation:
Chair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. roy@biozentrum.uni-wuerzburg.de
Citation:
The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae. 2008, 9:449 BMC Genomics
Journal:
BMC genomics
Issue Date:
2008
URI:
http://hdl.handle.net/10033/42254
DOI:
10.1186/1471-2164-9-449
PubMed ID:
18826580
Additional Links:
http://www.biomedcentral.com/1471-2164/9/449
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorGross, Royen
dc.contributor.authorGuzman, Carlos Aen
dc.contributor.authorSebaihia, Mohammeden
dc.contributor.authordos Santos, Vítor A P Martinsen
dc.contributor.authorPieper, Dietmar Hen
dc.contributor.authorKoebnik, Ralfen
dc.contributor.authorLechner, Melanieen
dc.contributor.authorBartels, Danielaen
dc.contributor.authorBuhrmester, Jensen
dc.contributor.authorChoudhuri, Jomuna Ven
dc.contributor.authorEbensen, Thomasen
dc.contributor.authorGaigalat, Larsen
dc.contributor.authorHerrmann, Stefanieen
dc.contributor.authorKhachane, Amit Nen
dc.contributor.authorLarisch, Christofen
dc.contributor.authorLink, Stefanieen
dc.contributor.authorLinke, Burkharden
dc.contributor.authorMeyer, Folkeren
dc.contributor.authorMormann, Saschaen
dc.contributor.authorNakunst, Dianaen
dc.contributor.authorRückert, Christianen
dc.contributor.authorSchneiker-Bekel, Susanneen
dc.contributor.authorSchulze, Kaien
dc.contributor.authorVorhölter, Frank-Jörgen
dc.contributor.authorYevsa, Tetyanaen
dc.contributor.authorEngle, Jacquelyn Ten
dc.contributor.authorGoldman, William Een
dc.contributor.authorPühler, Alfreden
dc.contributor.authorGöbel, Ulf Ben
dc.contributor.authorGoesmann, Alexanderen
dc.contributor.authorBlöcker, Helmuten
dc.contributor.authorKaiser, Olafen
dc.contributor.authorMartinez-Arias, Rosaen
dc.date.accessioned2008-12-11T14:58:24Zen
dc.date.available2008-12-11T14:58:24Zen
dc.date.issued2008en
dc.identifier.citationThe missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae. 2008, 9:449 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid18826580en
dc.identifier.doi10.1186/1471-2164-9-449en
dc.identifier.urihttp://hdl.handle.net/10033/42254en
dc.description.abstractBACKGROUND: Bordetella petrii is the only environmental species hitherto found among the otherwise host-restricted and pathogenic members of the genus Bordetella. Phylogenetically, it connects the pathogenic Bordetellae and environmental bacteria of the genera Achromobacter and Alcaligenes, which are opportunistic pathogens. B. petrii strains have been isolated from very different environmental niches, including river sediment, polluted soil, marine sponges and a grass root. Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described. RESULTS: In this manuscript we present the results of the analysis of the completely annotated genome sequence of the B. petrii strain DSMZ12804. B. petrii has a mosaic genome of 5,287,950 bp harboring numerous mobile genetic elements, including seven large genomic islands. Four of them are highly related to the clc element of Pseudomonas knackmussii B13, which encodes genes involved in the degradation of aromatics. Though being an environmental isolate, the sequenced B. petrii strain also encodes proteins related to virulence factors of the pathogenic Bordetellae, including the filamentous hemagglutinin, which is a major colonization factor of B. pertussis, and the master virulence regulator BvgAS. However, it lacks all known toxins of the pathogenic Bordetellae. CONCLUSION: The genomic analysis suggests that B. petrii represents an evolutionary link between free-living environmental bacteria and the host-restricted obligate pathogenic Bordetellae. Its remarkable metabolic versatility may enable B. petrii to thrive in very different ecological niches.en
dc.language.isoenen
dc.relation.urlhttp://www.biomedcentral.com/1471-2164/9/449en
dc.subject.meshBacterial Proteinsen
dc.subject.meshBase Compositionen
dc.subject.meshBordetellaen
dc.subject.meshBordetella bronchisepticaen
dc.subject.meshBordetella parapertussisen
dc.subject.meshBordetella pertussisen
dc.subject.meshChromosomes, Bacterialen
dc.subject.meshEvolutionen
dc.subject.meshGenes, Bacterialen
dc.subject.meshGenome, Bacterialen
dc.subject.meshGenomic Libraryen
dc.subject.meshInterspersed Repetitive Sequencesen
dc.subject.meshMolecular Sequence Dataen
dc.subject.meshSyntenyen
dc.subject.meshVirulenceen
dc.subject.meshVirulence Factors, Bordetellaen
dc.titleThe missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae.en
dc.typeArticleen
dc.contributor.departmentChair of Microbiology, Biocenter, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany. roy@biozentrum.uni-wuerzburg.deen
dc.identifier.journalBMC genomicsen

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