2.50
Hdl Handle:
http://hdl.handle.net/10033/52253
Title:
PspA can form large scaffolds in Escherichia coli.
Authors:
Standar, Kerstin; Mehner, Denise; Osadnik, Hendrik; Berthelmann, Felix; Hause, Gerd; Lünsdorf, Heinrich; Brüser, Thomas
Abstract:
The phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.
Affiliation:
Institute of Biology/Microbiology, University of Halle-Wittenberg, Kurt-Mothes-Strasse 3, D-06120 Halle, Germany.
Citation:
PspA can form large scaffolds in Escherichia coli. 2008, 582 (25-26):3585-9 FEBS Lett.
Journal:
FEBS letters
Issue Date:
29-Oct-2008
URI:
http://hdl.handle.net/10033/52253
DOI:
10.1016/j.febslet.2008.09.002
PubMed ID:
18789328
Type:
Article
Language:
en
ISSN:
0014-5793
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorStandar, Kerstin-
dc.contributor.authorMehner, Denise-
dc.contributor.authorOsadnik, Hendrik-
dc.contributor.authorBerthelmann, Felix-
dc.contributor.authorHause, Gerd-
dc.contributor.authorLünsdorf, Heinrich-
dc.contributor.authorBrüser, Thomas-
dc.date.accessioned2009-03-05T09:31:56Z-
dc.date.available2009-03-05T09:31:56Z-
dc.date.issued2008-10-29-
dc.identifier.citationPspA can form large scaffolds in Escherichia coli. 2008, 582 (25-26):3585-9 FEBS Lett.en
dc.identifier.issn0014-5793-
dc.identifier.pmid18789328-
dc.identifier.doi10.1016/j.febslet.2008.09.002-
dc.identifier.urihttp://hdl.handle.net/10033/52253-
dc.description.abstractThe phage shock protein A (PspA) of Escherichia coli stabilizes the cytoplasmic membrane under stress conditions. Here we demonstrate that PspA can form hollow spherical or prolate spheroidal particles of about 30-40nm diameter with a scaffold-like arrangement of protein subunits at the surface. The 'PspA-scaffold' is the basic structure that is common to all particles. The PspA-scaffold may be of fundamental importance, as it could allow PspA to stabilize the integrity of membranes through numerous contact points over a large surface area.en
dc.language.isoenen
dc.subject.meshBacterial Proteinsen
dc.subject.meshCell Membraneen
dc.subject.meshEscherichia colien
dc.subject.meshEscherichia coli Proteinsen
dc.subject.meshHeat-Shock Proteinsen
dc.titlePspA can form large scaffolds in Escherichia coli.en
dc.typeArticleen
dc.contributor.departmentInstitute of Biology/Microbiology, University of Halle-Wittenberg, Kurt-Mothes-Strasse 3, D-06120 Halle, Germany.en
dc.identifier.journalFEBS lettersen

Related articles on PubMed

All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.