TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.

2.50
Hdl Handle:
http://hdl.handle.net/10033/558698
Title:
TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.
Authors:
Dutruel, Céline; Thole, Jelle; Geels, Mark; Mollenkopf, Hans-Joachim; Ottenhoff, Tom; Guzman, Carlos A; Fletcher, Helen A; Leroy, Odile; Kaufmann, Stefan H E
Abstract:
High-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it is timely to consider standardisation and harmonisation of sample collection, storage and analysis to ensure results of highest quality from these precious samples. These challenges were discussed by a group of international experts during a workshop organised by TRANSVAC, a European Commission-funded Research Infrastructure project. The main conclusions were: Platforms are rarely standardised for use in preclinical and clinical studies. Coordinated efforts should continue to harmonise the experimental set up of these studies, as well as the establishment of internal standards and controls. This will ensure comparability, efficiency and feasibility of the global analyses performed on preclinical and clinical data sets.
Affiliation:
Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
Citation:
TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'. 2014, 32 (35):4365-8 Vaccine
Journal:
Vaccine
Issue Date:
31-Jul-2014
URI:
http://hdl.handle.net/10033/558698
DOI:
10.1016/j.vaccine.2014.06.014
PubMed ID:
24950356
Type:
Article
Language:
en
ISSN:
1873-2518
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorDutruel, Célineen
dc.contributor.authorThole, Jelleen
dc.contributor.authorGeels, Marken
dc.contributor.authorMollenkopf, Hans-Joachimen
dc.contributor.authorOttenhoff, Tomen
dc.contributor.authorGuzman, Carlos Aen
dc.contributor.authorFletcher, Helen Aen
dc.contributor.authorLeroy, Odileen
dc.contributor.authorKaufmann, Stefan H Een
dc.date.accessioned2015-06-30T13:40:51Zen
dc.date.available2015-06-30T13:40:51Zen
dc.date.issued2014-07-31en
dc.identifier.citationTRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'. 2014, 32 (35):4365-8 Vaccineen
dc.identifier.issn1873-2518en
dc.identifier.pmid24950356en
dc.identifier.doi10.1016/j.vaccine.2014.06.014en
dc.identifier.urihttp://hdl.handle.net/10033/558698en
dc.description.abstractHigh-throughput analyses of RNA and protein expression are increasingly used for better understanding of vaccine-induced immunity and protection against infectious disease. With an increasing number of vaccine candidates in clinical development, it is timely to consider standardisation and harmonisation of sample collection, storage and analysis to ensure results of highest quality from these precious samples. These challenges were discussed by a group of international experts during a workshop organised by TRANSVAC, a European Commission-funded Research Infrastructure project. The main conclusions were: Platforms are rarely standardised for use in preclinical and clinical studies. Coordinated efforts should continue to harmonise the experimental set up of these studies, as well as the establishment of internal standards and controls. This will ensure comparability, efficiency and feasibility of the global analyses performed on preclinical and clinical data sets.en
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/241745en
dc.rightsopenAccessen
dc.subject.meshAIDS Vaccinesen
dc.subject.meshBiomedical Researchen
dc.subject.meshHumansen
dc.subject.meshMalaria Vaccinesen
dc.subject.meshTuberculosis Vaccinesen
dc.subject.meshVaccinationen
dc.titleTRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: 'how can big data help?'.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.en
dc.identifier.journalVaccineen

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