5.00
Hdl Handle:
http://hdl.handle.net/10033/566265
Title:
A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.
Authors:
Dehghany, Jaber ( : 0000-0002-9719-8433 ) ; Hoboth, Peter; Ivanova, Anna; Mziaut, Hassan; Müller, Andreas; Kalaidzidis, Yannis; Solimena, Michele; Meyer-Hermann, Michael ( 0000-0002-4300-2474 )
Abstract:
Insulin secretion from pancreatic β-cells in response to sudden glucose stimulation is biphasic. Prolonged secretion in vivo requires synthesis, delivery to the plasma membrane (PM) and exocytosis of insulin secretory granules (SGs). Here, we provide the first agent-based space-resolved model for SG dynamics in pancreatic β-cells. Using recent experimental data, we consider a single β-cell with identical SGs moving on a phenomenologically represented cytoskeleton network. A single exocytotic machinery mediates SG exocytosis on the PM. This novel model reproduces the measured spatial organization of SGs and insulin secretion patterns under different stimulation protocols. It proposes that the insulin potentiation effect and the rising second-phase secretion are mainly due to the increasing number of docking sites on the PM. Furthermore, it shows that 6 min after glucose stimulation, the 'newcomer' SGs are recruited from a region within less than 600 nm from the PM.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
A Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells. 2015, 16 (8):797-813 Traffic
Journal:
Traffic (Copenhagen, Denmark)
Issue Date:
Aug-2015
URI:
http://hdl.handle.net/10033/566265
DOI:
10.1111/tra.12286
PubMed ID:
25809669
Type:
Article
Language:
en
ISSN:
1600-0854
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorDehghany, Jaberen
dc.contributor.authorHoboth, Peteren
dc.contributor.authorIvanova, Annaen
dc.contributor.authorMziaut, Hassanen
dc.contributor.authorMüller, Andreasen
dc.contributor.authorKalaidzidis, Yannisen
dc.contributor.authorSolimena, Micheleen
dc.contributor.authorMeyer-Hermann, Michaelen
dc.date.accessioned2015-08-13T09:04:22Zen
dc.date.available2015-08-13T09:04:22Zen
dc.date.issued2015-08en
dc.identifier.citationA Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells. 2015, 16 (8):797-813 Trafficen
dc.identifier.issn1600-0854en
dc.identifier.pmid25809669en
dc.identifier.doi10.1111/tra.12286en
dc.identifier.urihttp://hdl.handle.net/10033/566265en
dc.description.abstractInsulin secretion from pancreatic β-cells in response to sudden glucose stimulation is biphasic. Prolonged secretion in vivo requires synthesis, delivery to the plasma membrane (PM) and exocytosis of insulin secretory granules (SGs). Here, we provide the first agent-based space-resolved model for SG dynamics in pancreatic β-cells. Using recent experimental data, we consider a single β-cell with identical SGs moving on a phenomenologically represented cytoskeleton network. A single exocytotic machinery mediates SG exocytosis on the PM. This novel model reproduces the measured spatial organization of SGs and insulin secretion patterns under different stimulation protocols. It proposes that the insulin potentiation effect and the rising second-phase secretion are mainly due to the increasing number of docking sites on the PM. Furthermore, it shows that 6 min after glucose stimulation, the 'newcomer' SGs are recruited from a region within less than 600 nm from the PM.en
dc.language.isoenen
dc.titleA Spatial Model of Insulin-Granule Dynamics in Pancreatic β-Cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalTraffic (Copenhagen, Denmark)en

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