2.50
Hdl Handle:
http://hdl.handle.net/10033/576588
Title:
pH-triggered drug release from biodegradable microwells for oral drug delivery.
Authors:
Nielsen, Line Hagner; Nagstrup, Johan; Gordon, Sarah; Keller, Stephan Sylvest; Østergaard, Jesper; Rades, Thomas; Müllertz, Anette; Boisen, Anja
Abstract:
Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.
Citation:
pH-triggered drug release from biodegradable microwells for oral drug delivery. 2015, 17 (3):9958 Biomed Microdevices
Journal:
Biomedical microdevices
Issue Date:
Jun-2015
URI:
http://hdl.handle.net/10033/576588
DOI:
10.1007/s10544-015-9958-5
PubMed ID:
25981751
Type:
Article
Language:
en
ISSN:
1572-8781
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorNielsen, Line Hagneren
dc.contributor.authorNagstrup, Johanen
dc.contributor.authorGordon, Sarahen
dc.contributor.authorKeller, Stephan Sylvesten
dc.contributor.authorØstergaard, Jesperen
dc.contributor.authorRades, Thomasen
dc.contributor.authorMüllertz, Anetteen
dc.contributor.authorBoisen, Anjaen
dc.date.accessioned2015-09-03T13:58:39Zen
dc.date.available2015-09-03T13:58:39Zen
dc.date.issued2015-06en
dc.identifier.citationpH-triggered drug release from biodegradable microwells for oral drug delivery. 2015, 17 (3):9958 Biomed Microdevicesen
dc.identifier.issn1572-8781en
dc.identifier.pmid25981751en
dc.identifier.doi10.1007/s10544-015-9958-5en
dc.identifier.urihttp://hdl.handle.net/10033/576588en
dc.description.abstractMicrowells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.en
dc.language.isoenen
dc.titlepH-triggered drug release from biodegradable microwells for oral drug delivery.en
dc.typeArticleen
dc.identifier.journalBiomedical microdevicesen

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