Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease.

2.50
Hdl Handle:
http://hdl.handle.net/10033/577242
Title:
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease.
Authors:
Karch, André ( 0000-0003-3014-8543 ) ; Hermann, Peter; Ponto, Claudia; Schmitz, Matthias; Arora, Amandeep; Zafar, Saima; Llorens, Franc; Müller-Heine, Annika; Zerr, Inga
Abstract:
The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic marker for patient survival. However, subtype determination is not possible during lifetime. Because the rate of disease progression is associated with the molecular subtype, this study aimed at investigating if total tau, a marker of neuronal death, allows premortem diagnosis of molecular subtype when codon 129 genotype is known. Two hundred ninety-six sCJD patients were tested for their cerebrospinal fluid total tau level at the time of diagnosis and were investigated for their sCJD subtype postmortem. There was a significant association between tau levels and the prion protein type in patients with codon 129 MM (p < 0.001), MV (p = 0.004), and VV (p = 0.001) genotype. Receiver operating characteristic analyses showed values of area under the curve of 0.76-0.80 for the different genotypes indicating a good diagnostic validity of the test. Total tau can be used as a diagnostic test for the assessment of prion protein type when codon 129 genotype is known. It provides valuable information for physicians and next of kin about the further course of disease.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease. 2015, 36 (5):1964-8 Neurobiol. Aging
Journal:
Neurobiology of aging
Issue Date:
May-2015
URI:
http://hdl.handle.net/10033/577242
DOI:
10.1016/j.neurobiolaging.2015.01.021
PubMed ID:
25749129
Type:
Article
Language:
en
ISSN:
1558-1497
Appears in Collections:
Publications of the AG (ESME)

Full metadata record

DC FieldValue Language
dc.contributor.authorKarch, Andréen
dc.contributor.authorHermann, Peteren
dc.contributor.authorPonto, Claudiaen
dc.contributor.authorSchmitz, Matthiasen
dc.contributor.authorArora, Amandeepen
dc.contributor.authorZafar, Saimaen
dc.contributor.authorLlorens, Francen
dc.contributor.authorMüller-Heine, Annikaen
dc.contributor.authorZerr, Ingaen
dc.date.accessioned2015-09-14T13:58:08Zen
dc.date.available2015-09-14T13:58:08Zen
dc.date.issued2015-05en
dc.identifier.citationCerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease. 2015, 36 (5):1964-8 Neurobiol. Agingen
dc.identifier.issn1558-1497en
dc.identifier.pmid25749129en
dc.identifier.doi10.1016/j.neurobiolaging.2015.01.021en
dc.identifier.urihttp://hdl.handle.net/10033/577242en
dc.description.abstractThe molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic marker for patient survival. However, subtype determination is not possible during lifetime. Because the rate of disease progression is associated with the molecular subtype, this study aimed at investigating if total tau, a marker of neuronal death, allows premortem diagnosis of molecular subtype when codon 129 genotype is known. Two hundred ninety-six sCJD patients were tested for their cerebrospinal fluid total tau level at the time of diagnosis and were investigated for their sCJD subtype postmortem. There was a significant association between tau levels and the prion protein type in patients with codon 129 MM (p < 0.001), MV (p = 0.004), and VV (p = 0.001) genotype. Receiver operating characteristic analyses showed values of area under the curve of 0.76-0.80 for the different genotypes indicating a good diagnostic validity of the test. Total tau can be used as a diagnostic test for the assessment of prion protein type when codon 129 genotype is known. It provides valuable information for physicians and next of kin about the further course of disease.en
dc.language.isoenen
dc.titleCerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalNeurobiology of agingen

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