Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.

2.50
Hdl Handle:
http://hdl.handle.net/10033/577529
Title:
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.
Authors:
Koutsoudakis, George; Romero-Brey, Inés; Berger, Carola; Pérez-Vilaró, Gemma; Monteiro Perin, Paula; Vondran, Florian Wolfgang Rudolf; Kalesse, Markus; Harmrolfs, Kirsten; Müller, Rolf; Martinez, Javier P; Pietschmann, Thomas; Bartenschlager, Ralf; Brönstrup, Mark; Meyerhans, Andreas; Díez, Juana
Abstract:
Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human immunodeficiency virus (HIV). The aim of the present study was to evaluate the capacity of SorA and analogues to inhibit hepatitis C virus (HCV) infection.
Affiliation:
TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.
Citation:
Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. 2015: J. Hepatol.
Journal:
Journal of hepatology
Issue Date:
10-Jun-2015
URI:
http://hdl.handle.net/10033/577529
DOI:
10.1016/j.jhep.2015.06.002
PubMed ID:
26070407
Type:
Article
ISSN:
1600-0641
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorKoutsoudakis, Georgeen
dc.contributor.authorRomero-Brey, Inésen
dc.contributor.authorBerger, Carolaen
dc.contributor.authorPérez-Vilaró, Gemmaen
dc.contributor.authorMonteiro Perin, Paulaen
dc.contributor.authorVondran, Florian Wolfgang Rudolfen
dc.contributor.authorKalesse, Markusen
dc.contributor.authorHarmrolfs, Kirstenen
dc.contributor.authorMüller, Rolfen
dc.contributor.authorMartinez, Javier Pen
dc.contributor.authorPietschmann, Thomasen
dc.contributor.authorBartenschlager, Ralfen
dc.contributor.authorBrönstrup, Marken
dc.contributor.authorMeyerhans, Andreasen
dc.contributor.authorDíez, Juanaen
dc.date.accessioned2015-09-18T09:08:09Zen
dc.date.available2015-09-18T09:08:09Zen
dc.date.issued2015-06-10en
dc.identifier.citationSoraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity. 2015: J. Hepatol.en
dc.identifier.issn1600-0641en
dc.identifier.pmid26070407en
dc.identifier.doi10.1016/j.jhep.2015.06.002en
dc.identifier.urihttp://hdl.handle.net/10033/577529en
dc.description.abstractSoraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human immunodeficiency virus (HIV). The aim of the present study was to evaluate the capacity of SorA and analogues to inhibit hepatitis C virus (HCV) infection.en
dc.languageENGen
dc.titleSoraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen Str. 7, 30625, Hannover, Germany.en
dc.identifier.journalJournal of hepatologyen

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