Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

2.50
Hdl Handle:
http://hdl.handle.net/10033/578595
Title:
Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.
Authors:
Torow, Natalia; Yu, Kai; Hassani, Kasra; Freitag, Jenny; Schulz, Olga; Basic, Marijana; Brennecke, Anne; Sparwasser, Tim ( 0000-0001-5645-902X ) ; Wagner, Norbert; Bleich, André; Lochner, Matthias; Weiss, Siegfried; Förster, Reinhold; Pabst, Oliver; Hornef, Mathias W
Abstract:
Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis.
Affiliation:
TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School, Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Stra e 7, 30625 Hannover, Germany
Citation:
Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. 2015, 6:7725 Nat Commun
Journal:
Nature communications
Issue Date:
2015
URI:
http://hdl.handle.net/10033/578595
DOI:
10.1038/ncomms8725
PubMed ID:
26195040
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
publications of the TwinCore unit Infection immunology

Full metadata record

DC FieldValue Language
dc.contributor.authorTorow, Nataliaen
dc.contributor.authorYu, Kaien
dc.contributor.authorHassani, Kasraen
dc.contributor.authorFreitag, Jennyen
dc.contributor.authorSchulz, Olgaen
dc.contributor.authorBasic, Marijanaen
dc.contributor.authorBrennecke, Anneen
dc.contributor.authorSparwasser, Timen
dc.contributor.authorWagner, Norberten
dc.contributor.authorBleich, Andréen
dc.contributor.authorLochner, Matthiasen
dc.contributor.authorWeiss, Siegfrieden
dc.contributor.authorFörster, Reinholden
dc.contributor.authorPabst, Oliveren
dc.contributor.authorHornef, Mathias Wen
dc.date.accessioned2015-09-22T13:17:24Zen
dc.date.available2015-09-22T13:17:24Zen
dc.date.issued2015en
dc.identifier.citationActive suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. 2015, 6:7725 Nat Communen
dc.identifier.issn2041-1723en
dc.identifier.pmid26195040en
dc.identifier.doi10.1038/ncomms8725en
dc.identifier.urihttp://hdl.handle.net/10033/578595en
dc.description.abstractPriming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the small intestine and quickly acquire a distinct transcriptional profile. T-cell recruitment is independent of microbial colonization and innate or adaptive immune stimulation but requires β7 integrin expression. Surprisingly, neonatal CD4 T cells remain immature throughout the postnatal period under homeostatic conditions but undergo maturation and gain effector function on barrier disruption. Maternal SIgA and regulatory T cells act in concert to prevent immune stimulation and maintain the immature phenotype of CD4 T cells in the postnatal intestine during homeostasis. Active suppression of CD4 T-cell maturation during the postnatal period might contribute to prevent auto-reactivity, sustain a broad TCR repertoire and establish life-long immune homeostasis.en
dc.language.isoenen
dc.titleActive suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School, Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Feodor-Lynen-Stra e 7, 30625 Hannover, Germanyen
dc.identifier.journalNature communicationsen

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