RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/578689
Title:
RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.
Authors:
Wilk, Esther ( 0000-0003-3446-5511 ) ; Pandey, Ashutosh K; Leist, Sarah Rebecca; Hatesuer, Bastian; Preusse, Matthias; Pommerenke, Claudia ( 0000-0002-9448-416X ) ; Wang, Junxi; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
The host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilized a dual RNAseq approach that allowed us to investigate both viral and host gene expression in the same individual mouse after H1N1 infection.
Affiliation:
Helmholtz Centre for Infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection. 2015, 16:655 BMC Genomics
Journal:
BMC genomics
Issue Date:
2015
URI:
http://hdl.handle.net/10033/578689
DOI:
10.1186/s12864-015-1867-8
PubMed ID:
26329040
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorWilk, Estheren
dc.contributor.authorPandey, Ashutosh Ken
dc.contributor.authorLeist, Sarah Rebeccaen
dc.contributor.authorHatesuer, Bastianen
dc.contributor.authorPreusse, Matthiasen
dc.contributor.authorPommerenke, Claudiaen
dc.contributor.authorWang, Junxien
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2015-09-24T15:12:18Zen
dc.date.available2015-09-24T15:12:18Zen
dc.date.issued2015en
dc.identifier.citationRNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection. 2015, 16:655 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid26329040en
dc.identifier.doi10.1186/s12864-015-1867-8en
dc.identifier.urihttp://hdl.handle.net/10033/578689en
dc.description.abstractThe host response to influenza A infections is strongly influenced by host genetic factors. Animal models of genetically diverse mouse strains are well suited to identify host genes involved in severe pathology, viral replication and immune responses. Here, we have utilized a dual RNAseq approach that allowed us to investigate both viral and host gene expression in the same individual mouse after H1N1 infection.en
dc.language.isoenen
dc.titleRNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for Infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalBMC genomicsen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.