2.50
Hdl Handle:
http://hdl.handle.net/10033/579626
Title:
Rodents as pre-clinical models for predicting vaccine performance in humans.
Authors:
Riese, Peggy ( 0000-0001-6796-6780 ) ; Trittel, Stephanie; Schulze, Kai ( 0000-0003-2286-3416 ) ; Guzmán, Carlos A
Abstract:
Vaccines represent a key building block for establishing a successful and sustainable control strategy against infectious diseases. Vaccine development often depends on the availability of correlates for protection and reliable animal models for the screening, selection and prioritization of potential vaccine candidates. This is performed according to their immunogenicity, efficacy and safety profiles in pre-clinical studies, which are also critical for identification of candidate antigens, selection of an optimal delivery system and design of appropriate vaccine formulations. Thus, pre-clinical studies in animal models are a prerequisite for addressing crucial issues and generating a solid pre-clinical package for the approval of clinical trials. This review addresses the strengths, limitations and perspectives of rodents as a vaccine development and pre-clinical validation tool.
Citation:
Rodents as pre-clinical models for predicting vaccine performance in humans. 2015, 14 (9):1213-25 Expert Rev Vaccines
Journal:
Expert review of vaccines
Issue Date:
Sep-2015
URI:
http://hdl.handle.net/10033/579626
PubMed ID:
26268433
Type:
Article
Language:
en
ISSN:
1744-8395
Appears in Collections:
publications of the research group vaccinology and applied microbiology (VAC)

Full metadata record

DC FieldValue Language
dc.contributor.authorRiese, Peggyen
dc.contributor.authorTrittel, Stephanieen
dc.contributor.authorSchulze, Kaien
dc.contributor.authorGuzmán, Carlos Aen
dc.date.accessioned2015-10-14T13:02:28Zen
dc.date.available2015-10-14T13:02:28Zen
dc.date.issued2015-09en
dc.identifier.citationRodents as pre-clinical models for predicting vaccine performance in humans. 2015, 14 (9):1213-25 Expert Rev Vaccinesen
dc.identifier.issn1744-8395en
dc.identifier.pmid26268433en
dc.identifier.urihttp://hdl.handle.net/10033/579626en
dc.description.abstractVaccines represent a key building block for establishing a successful and sustainable control strategy against infectious diseases. Vaccine development often depends on the availability of correlates for protection and reliable animal models for the screening, selection and prioritization of potential vaccine candidates. This is performed according to their immunogenicity, efficacy and safety profiles in pre-clinical studies, which are also critical for identification of candidate antigens, selection of an optimal delivery system and design of appropriate vaccine formulations. Thus, pre-clinical studies in animal models are a prerequisite for addressing crucial issues and generating a solid pre-clinical package for the approval of clinical trials. This review addresses the strengths, limitations and perspectives of rodents as a vaccine development and pre-clinical validation tool.en
dc.language.isoenen
dc.titleRodents as pre-clinical models for predicting vaccine performance in humans.en
dc.typeArticleen
dc.identifier.journalExpert review of vaccinesen

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