Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.

2.50
Hdl Handle:
http://hdl.handle.net/10033/579735
Title:
Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.
Authors:
Martins, José Paulo; Santos, Jorge Miguel; de Almeida, Joana Marto; Filipe, Mariana Alves; de Almeida, Mariana Vargas Teixeira; Almeida, Sílvia Cristina Paiva; Água-Doce, Ana; Varela, Alexandre; Gilljam, Mari; Stellan, Birgitta; Pohl, Susanne; Dittmar, Kurt; Lindenmaier, Werner; Alici, Evren; Graça, Luís; Cruz, Pedro Estilita; Cruz, Helder Joaquim; Bárcia, Rita Nogueira
Abstract:
Standardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of MSCs, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product (ATMP).
Citation:
Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data. 2014, 5 (1):9 Stem Cell Res Ther
Journal:
Stem cell research & therapy
Issue Date:
2014
URI:
http://hdl.handle.net/10033/579735
DOI:
10.1186/scrt398
PubMed ID:
24438697
Type:
Article
Language:
en
ISSN:
1757-6512
Appears in Collections:
Publications of Dept. Gene Regulation and Differentiation (RDIF)

Full metadata record

DC FieldValue Language
dc.contributor.authorMartins, José Pauloen
dc.contributor.authorSantos, Jorge Miguelen
dc.contributor.authorde Almeida, Joana Martoen
dc.contributor.authorFilipe, Mariana Alvesen
dc.contributor.authorde Almeida, Mariana Vargas Teixeiraen
dc.contributor.authorAlmeida, Sílvia Cristina Paivaen
dc.contributor.authorÁgua-Doce, Anaen
dc.contributor.authorVarela, Alexandreen
dc.contributor.authorGilljam, Marien
dc.contributor.authorStellan, Birgittaen
dc.contributor.authorPohl, Susanneen
dc.contributor.authorDittmar, Kurten
dc.contributor.authorLindenmaier, Werneren
dc.contributor.authorAlici, Evrenen
dc.contributor.authorGraça, Luísen
dc.contributor.authorCruz, Pedro Estilitaen
dc.contributor.authorCruz, Helder Joaquimen
dc.contributor.authorBárcia, Rita Nogueiraen
dc.date.accessioned2015-10-15T08:26:57Zen
dc.date.available2015-10-15T08:26:57Zen
dc.date.issued2014en
dc.identifier.citationTowards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data. 2014, 5 (1):9 Stem Cell Res Theren
dc.identifier.issn1757-6512en
dc.identifier.pmid24438697en
dc.identifier.doi10.1186/scrt398en
dc.identifier.urihttp://hdl.handle.net/10033/579735en
dc.description.abstractStandardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of MSCs, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product (ATMP).en
dc.language.isoenen
dc.subject.meshCells, Cultureden
dc.subject.meshCryopreservationen
dc.subject.meshHumansen
dc.subject.meshMesenchymal Stem Cell Transplantationen
dc.subject.meshMesenchymal Stromal Cellsen
dc.subject.meshQuality Controlen
dc.subject.meshStem Cell Researchen
dc.subject.meshTissue and Organ Harvestingen
dc.subject.meshUmbilical Corden
dc.titleTowards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.en
dc.typeArticleen
dc.identifier.journalStem cell research & therapyen

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