Negative interactions and feedback regulations are required for transient cellular response.

2.50
Hdl Handle:
http://hdl.handle.net/10033/581695
Title:
Negative interactions and feedback regulations are required for transient cellular response.
Authors:
Mobashir, Mohammad; Madhusudhan, Thati; Isermann, Berend; Beyer, Tilo; Schraven, Burkhart
Abstract:
Signal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics of signaling activation and inhibition determine processes such as apoptosis, proliferation, and differentiation. Thus, it is important to understand the factors modulating transient and sustained response. To address this question, by applying mathematical approach we have studied the factors which can alter the activation nature of downstream signaling molecules. The factors which we have investigated are loops (feed forward and feedback loops), cross-talk of signal transduction pathways, and the change in the concentration of the signaling molecules. Based on our results we conclude that among these factors feedback loop and the cross-talks which directly inhibit the target protein dominantly controls the transient cellular response.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Negative interactions and feedback regulations are required for transient cellular response. 2014, 4:3718 Sci Rep
Journal:
Scientific reports
Issue Date:
2014
URI:
http://hdl.handle.net/10033/581695
DOI:
10.1038/srep03718
PubMed ID:
24430195
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the department of immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorMobashir, Mohammaden
dc.contributor.authorMadhusudhan, Thatien
dc.contributor.authorIsermann, Berenden
dc.contributor.authorBeyer, Tiloen
dc.contributor.authorSchraven, Burkharten
dc.date.accessioned2015-11-04T10:51:12Zen
dc.date.available2015-11-04T10:51:12Zen
dc.date.issued2014en
dc.identifier.citationNegative interactions and feedback regulations are required for transient cellular response. 2014, 4:3718 Sci Repen
dc.identifier.issn2045-2322en
dc.identifier.pmid24430195en
dc.identifier.doi10.1038/srep03718en
dc.identifier.urihttp://hdl.handle.net/10033/581695en
dc.description.abstractSignal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics of signaling activation and inhibition determine processes such as apoptosis, proliferation, and differentiation. Thus, it is important to understand the factors modulating transient and sustained response. To address this question, by applying mathematical approach we have studied the factors which can alter the activation nature of downstream signaling molecules. The factors which we have investigated are loops (feed forward and feedback loops), cross-talk of signal transduction pathways, and the change in the concentration of the signaling molecules. Based on our results we conclude that among these factors feedback loop and the cross-talks which directly inhibit the target protein dominantly controls the transient cellular response.en
dc.language.isoenen
dc.subject.meshCell Physiological Phenomenaen
dc.subject.meshFeedback, Physiologicalen
dc.subject.meshModels, Biologicalen
dc.subject.meshSignal Transductionen
dc.titleNegative interactions and feedback regulations are required for transient cellular response.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalScientific reportsen
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