NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.

2.50
Hdl Handle:
http://hdl.handle.net/10033/581714
Title:
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Authors:
Simma, Narasimhulu; Bose, Tanima; Kahlfuss, Sascha; Mankiewicz, Judith; Lowinus, Theresa; Lühder, Fred; Schüler, Thomas; Schraven, Burkhart; Heine, Martin; Bommhardt, Ursula
Abstract:
B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. 2014, 12:75 Cell Commun. Signal
Journal:
Cell communication and signaling : CCS
Issue Date:
2014
URI:
http://hdl.handle.net/10033/581714
DOI:
10.1186/s12964-014-0075-5
PubMed ID:
25477292
Type:
Article
Language:
en
ISSN:
1478-811X
Appears in Collections:
publications of the department immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorSimma, Narasimhuluen
dc.contributor.authorBose, Tanimaen
dc.contributor.authorKahlfuss, Saschaen
dc.contributor.authorMankiewicz, Judithen
dc.contributor.authorLowinus, Theresaen
dc.contributor.authorLühder, Freden
dc.contributor.authorSchüler, Thomasen
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorHeine, Martinen
dc.contributor.authorBommhardt, Ursulaen
dc.date.accessioned2015-11-04T12:50:47Zen
dc.date.available2015-11-04T12:50:47Zen
dc.date.issued2014en
dc.identifier.citationNMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. 2014, 12:75 Cell Commun. Signalen
dc.identifier.issn1478-811Xen
dc.identifier.pmid25477292en
dc.identifier.doi10.1186/s12964-014-0075-5en
dc.identifier.urihttp://hdl.handle.net/10033/581714en
dc.description.abstractB cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function.en
dc.language.isoenen
dc.subject.meshAnimalsen
dc.subject.meshAntigens, CD40en
dc.subject.meshApoptosisen
dc.subject.meshB-Lymphocytesen
dc.subject.meshCell Proliferationen
dc.subject.meshImmunoglobulin Gen
dc.subject.meshImmunoglobulin Men
dc.subject.meshInterferon-gammaen
dc.subject.meshInterleukin-10en
dc.subject.meshIntermediate-Conductance Calcium-Activated Potassium Channelsen
dc.subject.meshKv1.3 Potassium Channelen
dc.subject.meshLipopolysaccharidesen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Transgenicen
dc.subject.meshPiperidinesen
dc.subject.meshReceptors, Antigen, B-Cellen
dc.subject.meshReceptors, N-Methyl-D-Aspartateen
dc.subject.meshToll-Like Receptor 4en
dc.titleNMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalCell communication and signaling : CCSen

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