Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.

3.00
Hdl Handle:
http://hdl.handle.net/10033/581961
Title:
Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.
Authors:
Marandu, Thomas F; Oduro, Jennifer D; Borkner, Lisa; Dekhtiarenko, Iryna; Uhrlaub, Jennifer L; Drabig, Anja; Kröger, Andrea ( 0000-0002-3131-6580 ) ; Nikolich-Zugich, Janko; Cicin-Sain, Luka ( 0000-0003-3978-778X )
Abstract:
Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections. 2015, 89 (22):11715-7 J. Virol.
Journal:
Journal of virology
Issue Date:
15-Nov-2015
URI:
http://hdl.handle.net/10033/581961
DOI:
10.1128/JVI.01989-15
PubMed ID:
26339051
Type:
Article
Language:
en
ISSN:
1098-5514
Appears in Collections:
publications of the research group immunity and infection (IMMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorMarandu, Thomas Fen
dc.contributor.authorOduro, Jennifer Den
dc.contributor.authorBorkner, Lisaen
dc.contributor.authorDekhtiarenko, Irynaen
dc.contributor.authorUhrlaub, Jennifer Len
dc.contributor.authorDrabig, Anjaen
dc.contributor.authorKröger, Andreaen
dc.contributor.authorNikolich-Zugich, Jankoen
dc.contributor.authorCicin-Sain, Lukaen
dc.date.accessioned2015-11-09T13:51:23Zen
dc.date.available2015-11-09T13:51:23Zen
dc.date.issued2015-11-15en
dc.identifier.citationImmune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections. 2015, 89 (22):11715-7 J. Virol.en
dc.identifier.issn1098-5514en
dc.identifier.pmid26339051en
dc.identifier.doi10.1128/JVI.01989-15en
dc.identifier.urihttp://hdl.handle.net/10033/581961en
dc.description.abstractLatent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.en
dc.language.isoenen
dc.titleImmune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalJournal of virologyen

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