Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.

2.50
Hdl Handle:
http://hdl.handle.net/10033/593546
Title:
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.
Authors:
Prajeeth, Chittappen K; Beineke, Andreas; Iskandar, Cut Dahlia; Gudi, Viktoria; Herder, Vanessa; Gerhauser, Ingo; Haist, Verena; Teich, René; Huehn, Jochen; Baumgärtner, Wolfgang; Stangel, Martin
Abstract:
Theiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS partly contributes to viral persistence and progressive demyelination. On the other hand, resistant C57BL/6 mice rapidly clear the virus by mounting a strong antiviral immune response. However, very little is known about the role of Tregs in regulating antiviral responses during acute encephalitis in resistant mouse strains.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. 2014, 11:180 J Neuroinflammation
Journal:
Journal of neuroinflammation
Issue Date:
2014
URI:
http://hdl.handle.net/10033/593546
DOI:
10.1186/s12974-014-0180-9
PubMed ID:
25391297
Type:
Article
Language:
en
ISSN:
1742-2094
Appears in Collections:
publications of the division experimentelle Immunologie (EXIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorPrajeeth, Chittappen Ken
dc.contributor.authorBeineke, Andreasen
dc.contributor.authorIskandar, Cut Dahliaen
dc.contributor.authorGudi, Viktoriaen
dc.contributor.authorHerder, Vanessaen
dc.contributor.authorGerhauser, Ingoen
dc.contributor.authorHaist, Verenaen
dc.contributor.authorTeich, Renéen
dc.contributor.authorHuehn, Jochenen
dc.contributor.authorBaumgärtner, Wolfgangen
dc.contributor.authorStangel, Martinen
dc.date.accessioned2016-01-15T14:12:36Zen
dc.date.available2016-01-15T14:12:36Zen
dc.date.issued2014en
dc.identifier.citationLimited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. 2014, 11:180 J Neuroinflammationen
dc.identifier.issn1742-2094en
dc.identifier.pmid25391297en
dc.identifier.doi10.1186/s12974-014-0180-9en
dc.identifier.urihttp://hdl.handle.net/10033/593546en
dc.description.abstractTheiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS partly contributes to viral persistence and progressive demyelination. On the other hand, resistant C57BL/6 mice rapidly clear the virus by mounting a strong antiviral immune response. However, very little is known about the role of Tregs in regulating antiviral responses during acute encephalitis in resistant mouse strains.en
dc.language.isoenen
dc.subject.meshAcute Diseaseen
dc.subject.meshAnimalsen
dc.subject.meshCardiovirus Infectionsen
dc.subject.meshDisease Resistanceen
dc.subject.meshEncephalitis, Viralen
dc.subject.meshMaleen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred C57BLen
dc.subject.meshMice, Transgenicen
dc.subject.meshT-Lymphocytes, Regulatoryen
dc.subject.meshTheilovirusen
dc.titleLimited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalJournal of neuroinflammationen

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