The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.

2.50
Hdl Handle:
http://hdl.handle.net/10033/594419
Title:
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Authors:
Krause-Gruszczynska, Malgorzata; Boehm, Manja; Rohde, Manfred ( 0000-0003-0522-3580 ) ; Tegtmeyer, Nicole; Takahashi, Seiichiro; Buday, Laszlo; Oyarzabal, Omar A; Backert, Steffen
Abstract:
Host cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. It was reported that small Rho GTPases, including Cdc42, are activated and play a role during invasion, but the involved signaling cascades remained unknown. Here we utilised knockout cell lines derived from fibronectin-/-, integrin-beta1-/-, focal adhesion kinase (FAK)-/- and Src/Yes/Fyn-/- deficient mice, and wild-type control cells, to investigate C. jejuni-induced mechanisms leading to Cdc42 activation and bacterial uptake.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Citation:
The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. 2011, 9:32 Cell Commun. Signal
Journal:
Cell communication and signaling : CCS
Issue Date:
2011
URI:
http://hdl.handle.net/10033/594419
DOI:
10.1186/1478-811X-9-32
PubMed ID:
22204307
Type:
Article
Language:
en
ISSN:
1478-811X
Appears in Collections:
publications of the central unit for microscopy (ZEIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorKrause-Gruszczynska, Malgorzataen
dc.contributor.authorBoehm, Manjaen
dc.contributor.authorRohde, Manfreden
dc.contributor.authorTegtmeyer, Nicoleen
dc.contributor.authorTakahashi, Seiichiroen
dc.contributor.authorBuday, Laszloen
dc.contributor.authorOyarzabal, Omar Aen
dc.contributor.authorBackert, Steffenen
dc.date.accessioned2016-01-20T15:11:29Zen
dc.date.available2016-01-20T15:11:29Zen
dc.date.issued2011en
dc.identifier.citationThe signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2. 2011, 9:32 Cell Commun. Signalen
dc.identifier.issn1478-811Xen
dc.identifier.pmid22204307en
dc.identifier.doi10.1186/1478-811X-9-32en
dc.identifier.urihttp://hdl.handle.net/10033/594419en
dc.description.abstractHost cell invasion by the foodborne pathogen Campylobacter jejuni is considered as one of the primary reasons of gut tissue damage, however, mechanisms and key factors involved in this process are widely unclear. It was reported that small Rho GTPases, including Cdc42, are activated and play a role during invasion, but the involved signaling cascades remained unknown. Here we utilised knockout cell lines derived from fibronectin-/-, integrin-beta1-/-, focal adhesion kinase (FAK)-/- and Src/Yes/Fyn-/- deficient mice, and wild-type control cells, to investigate C. jejuni-induced mechanisms leading to Cdc42 activation and bacterial uptake.en
dc.language.isoenen
dc.titleThe signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.en
dc.identifier.journalCell communication and signaling : CCSen

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