Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.
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Authors
Guillot, AlexisCouffin, Anne-Claude
Sejean, Xavier
Navarro, Fabrice
Limberger, Markus
Lehr, Claus-Michael
Issue Date
2015-12
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Show full item recordAbstract
Contrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.Citation
Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles. 2015, 32 (12):3999-4009 Pharm. Res.Affiliation
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.Journal
Pharmaceutical researchPubMed ID
26202518Type
ArticleLanguage
enISSN
1573-904Xae974a485f413a2113503eed53cd6c53
10.1007/s11095-015-1761-8
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