The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products.

2.50
Hdl Handle:
http://hdl.handle.net/10033/599277
Title:
The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products.
Authors:
Sabirova, Julia S ( 0000-0002-7381-4748 ) ; Haddouche, R; Van Bogaert, I N; Mulaa, F; Verstraete, W; Timmis, K N; Schmidt-Dannert, C; Nicaud, J M; Soetaert, W
Abstract:
The oleochemical industry is currently still dominated by conventional chemistry, with biotechnology only starting to play a more prominent role, primarily with respect to the biosurfactants or lipases, e.g. as detergents, or for biofuel production. A major bottleneck for all further biotechnological applications is the problem of the initial mobilization of cheap and vastly available lipid and oil substrates, which are then to be transformed into high-value biotechnological, nutritional or pharmacological products. Under the EU-sponsored LipoYeasts project we are developing the oleaginous yeast Yarrowia lipolytica into a versatile and high-throughput microbial factory that, by use of specific enzymatic pathways from hydrocarbonoclastic bacteria, efficiently mobilizes lipids by directing its versatile lipid metabolism towards the production of industrially valuable lipid-derived compounds like wax esters (WE), isoprenoid-derived compounds (carotenoids, polyenic carotenoid ester), polyhydroxyalkanoates (PHAs) and free hydroxylated fatty acids (HFAs). Different lipid stocks (petroleum, alkane, vegetable oil, fatty acid) and combinations thereof are being assessed as substrates in combination with different mutant and recombinant strains of Y. lipolytica, in order to modulate the composition and yields of the produced added-value products.
Affiliation:
Gesellschaft für biotechnologische Forschung (GBF), Mascheroder Weg 1, D-38124 Braunschweig, >Germany.
Citation:
The 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products. 2011, 4 (1):47-54 Microb Biotechnol
Journal:
Microbial biotechnology
Issue Date:
Jan-2011
URI:
http://hdl.handle.net/10033/599277
DOI:
10.1111/j.1751-7915.2010.00187.x
PubMed ID:
21255371
Type:
Article
Language:
en
ISSN:
1751-7915
Appears in Collections:
Publications of RG Environmental Microbiology (UMW)

Full metadata record

DC FieldValue Language
dc.contributor.authorSabirova, Julia Sen
dc.contributor.authorHaddouche, Ren
dc.contributor.authorVan Bogaert, I Nen
dc.contributor.authorMulaa, Fen
dc.contributor.authorVerstraete, Wen
dc.contributor.authorTimmis, K Nen
dc.contributor.authorSchmidt-Dannert, Cen
dc.contributor.authorNicaud, J Men
dc.contributor.authorSoetaert, Wen
dc.date.accessioned2016-02-26T10:49:07Zen
dc.date.available2016-02-26T10:49:07Zen
dc.date.issued2011-01en
dc.identifier.citationThe 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products. 2011, 4 (1):47-54 Microb Biotechnolen
dc.identifier.issn1751-7915en
dc.identifier.pmid21255371en
dc.identifier.doi10.1111/j.1751-7915.2010.00187.xen
dc.identifier.urihttp://hdl.handle.net/10033/599277en
dc.description.abstractThe oleochemical industry is currently still dominated by conventional chemistry, with biotechnology only starting to play a more prominent role, primarily with respect to the biosurfactants or lipases, e.g. as detergents, or for biofuel production. A major bottleneck for all further biotechnological applications is the problem of the initial mobilization of cheap and vastly available lipid and oil substrates, which are then to be transformed into high-value biotechnological, nutritional or pharmacological products. Under the EU-sponsored LipoYeasts project we are developing the oleaginous yeast Yarrowia lipolytica into a versatile and high-throughput microbial factory that, by use of specific enzymatic pathways from hydrocarbonoclastic bacteria, efficiently mobilizes lipids by directing its versatile lipid metabolism towards the production of industrially valuable lipid-derived compounds like wax esters (WE), isoprenoid-derived compounds (carotenoids, polyenic carotenoid ester), polyhydroxyalkanoates (PHAs) and free hydroxylated fatty acids (HFAs). Different lipid stocks (petroleum, alkane, vegetable oil, fatty acid) and combinations thereof are being assessed as substrates in combination with different mutant and recombinant strains of Y. lipolytica, in order to modulate the composition and yields of the produced added-value products.en
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/213068en
dc.rightsopenAccessen
dc.subject.meshBacteriaen
dc.subject.meshBacterial Proteinsen
dc.subject.meshBiotransformationen
dc.subject.meshGenetic Engineeringen
dc.subject.meshLipid Metabolismen
dc.subject.meshYarrowiaen
dc.titleThe 'LipoYeasts' project: using the oleaginous yeast Yarrowia lipolytica in combination with specific bacterial genes for the bioconversion of lipids, fats and oils into high-value products.en
dc.typeArticleen
dc.contributor.departmentGesellschaft für biotechnologische Forschung (GBF), Mascheroder Weg 1, D-38124 Braunschweig, >Germany.en
dc.identifier.journalMicrobial biotechnologyen

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.