Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.

2.50
Hdl Handle:
http://hdl.handle.net/10033/600890
Title:
Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.
Authors:
Axenov-Gibanov, Denis V; Voytsekhovskaya, Irina V; Tokovenko, Bogdan T; Protasov, Eugeniy S; Gamaiunov, Stanislav V; Rebets, Yuriy V; Luzhetskyy, Andriy N ( 0000-0001-6497-0047 ) ; Timofeyev, Maxim A
Abstract:
Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany, 3 Universität des Saarlandes–Pharmazeutische Biotechnologie, Saarbrucken, Germany.
Citation:
Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. 2016, 11 (2):e0149216 PLoS ONE
Journal:
PloS one
Issue Date:
2016
URI:
http://hdl.handle.net/10033/600890
DOI:
10.1371/journal.pone.0149216
PubMed ID:
26901168
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the research group metabolic engineering of Actinomycetes ([HIPS]AMEG)

Full metadata record

DC FieldValue Language
dc.contributor.authorAxenov-Gibanov, Denis Ven
dc.contributor.authorVoytsekhovskaya, Irina Ven
dc.contributor.authorTokovenko, Bogdan Ten
dc.contributor.authorProtasov, Eugeniy Sen
dc.contributor.authorGamaiunov, Stanislav Ven
dc.contributor.authorRebets, Yuriy Ven
dc.contributor.authorLuzhetskyy, Andriy Nen
dc.contributor.authorTimofeyev, Maxim Aen
dc.date.accessioned2016-03-08T13:24:21Zen
dc.date.available2016-03-08T13:24:21Zen
dc.date.issued2016en
dc.identifier.citationActinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds. 2016, 11 (2):e0149216 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid26901168en
dc.identifier.doi10.1371/journal.pone.0149216en
dc.identifier.urihttp://hdl.handle.net/10033/600890en
dc.description.abstractActinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.en
dc.language.isoenen
dc.titleActinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany, 3 Universität des Saarlandes–Pharmazeutische Biotechnologie, Saarbrucken, Germany.en
dc.identifier.journalPloS oneen

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