2.50
Hdl Handle:
http://hdl.handle.net/10033/600943
Title:
Functional modules of sigma factor regulons guarantee adaptability and evolvability.
Authors:
Binder, Sebastian C ( 0000-0003-1169-1786 ) ; Eckweiler, Denitsa; Schulz, Sebastian; Bielecka, Agata; Nicolai, Tanja; Franke, Raimo; Häussler, Susanne; Meyer-Hermann, Michael ( 0000-0002-4300-2474 )
Abstract:
The focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.
Affiliation:
Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Citation:
Functional modules of sigma factor regulons guarantee adaptability and evolvability. 2016, 6:22212 Sci Rep
Journal:
Scientific reports
Issue Date:
2016
URI:
http://hdl.handle.net/10033/600943
DOI:
10.1038/srep22212
PubMed ID:
26915971
Type:
Article
Language:
en
ISSN:
2045-2322
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorBinder, Sebastian Cen
dc.contributor.authorEckweiler, Denitsaen
dc.contributor.authorSchulz, Sebastianen
dc.contributor.authorBielecka, Agataen
dc.contributor.authorNicolai, Tanjaen
dc.contributor.authorFranke, Raimoen
dc.contributor.authorHäussler, Susanneen
dc.contributor.authorMeyer-Hermann, Michaelen
dc.date.accessioned2016-03-08T15:02:28Zen
dc.date.available2016-03-08T15:02:28Zen
dc.date.issued2016en
dc.identifier.citationFunctional modules of sigma factor regulons guarantee adaptability and evolvability. 2016, 6:22212 Sci Repen
dc.identifier.issn2045-2322en
dc.identifier.pmid26915971en
dc.identifier.doi10.1038/srep22212en
dc.identifier.urihttp://hdl.handle.net/10033/600943en
dc.description.abstractThe focus of modern molecular biology turns from assigning functions to individual genes towards understanding the expression and regulation of complex sets of molecules. Here, we provide evidence that alternative sigma factor regulons in the pathogen Pseudomonas aeruginosa largely represent insulated functional modules which provide a critical level of biological organization involved in general adaptation and survival processes. Analysis of the operational state of the sigma factor network revealed that transcription factors functionally couple the sigma factor regulons and significantly modulate the transcription levels in the face of challenging environments. The threshold quality of newly evolved transcription factors was reached faster and more robustly in in silico testing when the structural organization of sigma factor networks was taken into account. These results indicate that the modular structures of alternative sigma factor regulons provide P. aeruginosa with a robust framework to function adequately in its environment and at the same time facilitate evolutionary change. Our data support the view that widespread modularity guarantees robustness of biological networks and is a key driver of evolvability.en
dc.language.isoenen
dc.titleFunctional modules of sigma factor regulons guarantee adaptability and evolvability.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.en
dc.identifier.journalScientific reportsen
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