2.50
Hdl Handle:
http://hdl.handle.net/10033/601041
Title:
Investigations to the Antibacterial Mechanism of Action of Kendomycin.
Authors:
A Elnakady, Yasser; Chatterjee, Indranil; Bischoff, Markus; Rohde, Manfred ( 0000-0003-0522-3580 ) ; Josten, Michaele; Sahl, Hans-Georg; Herrmann, Mathias; Müller, Rolf ( 0000-0002-1042-5665 )
Abstract:
The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified.
Affiliation:
Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
Citation:
Investigations to the Antibacterial Mechanism of Action of Kendomycin. 2016, 11 (1):e0146165 PLoS ONE
Journal:
PloS one
Issue Date:
2016
URI:
http://hdl.handle.net/10033/601041
DOI:
10.1371/journal.pone.0146165
PubMed ID:
26795276
Type:
Article
Language:
en
ISSN:
1932-6203
Appears in Collections:
publications of the department of microbial natural substances ([HIPS]MINS)

Full metadata record

DC FieldValue Language
dc.contributor.authorA Elnakady, Yasseren
dc.contributor.authorChatterjee, Indranilen
dc.contributor.authorBischoff, Markusen
dc.contributor.authorRohde, Manfreden
dc.contributor.authorJosten, Michaeleen
dc.contributor.authorSahl, Hans-Georgen
dc.contributor.authorHerrmann, Mathiasen
dc.contributor.authorMüller, Rolfen
dc.date.accessioned2016-03-09T15:48:40Zen
dc.date.available2016-03-09T15:48:40Zen
dc.date.issued2016en
dc.identifier.citationInvestigations to the Antibacterial Mechanism of Action of Kendomycin. 2016, 11 (1):e0146165 PLoS ONEen
dc.identifier.issn1932-6203en
dc.identifier.pmid26795276en
dc.identifier.doi10.1371/journal.pone.0146165en
dc.identifier.urihttp://hdl.handle.net/10033/601041en
dc.description.abstractThe emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified.en
dc.language.isoenen
dc.titleInvestigations to the Antibacterial Mechanism of Action of Kendomycin.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.en
dc.identifier.journalPloS oneen

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