Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
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Authors
Kurhade, ChaitanyaZegenhagen, Loreen
Weber, Elvira
Nair, Sharmila
Michaelsen-Preusse, Kristin
Spanier, Julia
Gekara, Nelson O
Kröger, Andrea
Överby, Anna K
Issue Date
2016
Metadata
Show full item recordAbstract
Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.Citation
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. 2016, 13 (1):22 J NeuroinflammationAffiliation
Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.Journal
Journal of neuroinflammationPubMed ID
26819220Type
ArticleLanguage
enISSN
1742-2094ae974a485f413a2113503eed53cd6c53
10.1186/s12974-016-0487-9
Scopus Count
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