Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.

2.50
Hdl Handle:
http://hdl.handle.net/10033/601142
Title:
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
Authors:
Kurhade, Chaitanya; Zegenhagen, Loreen; Weber, Elvira; Nair, Sharmila; Michaelsen-Preusse, Kristin; Spanier, Julia; Gekara, Nelson O; Kröger, Andrea ( 0000-0002-3131-6580 ) ; Överby, Anna K
Abstract:
Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.
Affiliation:
Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Citation:
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. 2016, 13 (1):22 J Neuroinflammation
Journal:
Journal of neuroinflammation
Issue Date:
2016
URI:
http://hdl.handle.net/10033/601142
DOI:
10.1186/s12974-016-0487-9
PubMed ID:
26819220
Type:
Article
Language:
en
ISSN:
1742-2094
Appears in Collections:
publications of the research group intravital microscopy in infection and immunity (INMI)

Full metadata record

DC FieldValue Language
dc.contributor.authorKurhade, Chaitanyaen
dc.contributor.authorZegenhagen, Loreenen
dc.contributor.authorWeber, Elviraen
dc.contributor.authorNair, Sharmilaen
dc.contributor.authorMichaelsen-Preusse, Kristinen
dc.contributor.authorSpanier, Juliaen
dc.contributor.authorGekara, Nelson Oen
dc.contributor.authorKröger, Andreaen
dc.contributor.authorÖverby, Anna Ken
dc.date.accessioned2016-03-10T15:28:49Zen
dc.date.available2016-03-10T15:28:49Zen
dc.date.issued2016en
dc.identifier.citationType I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. 2016, 13 (1):22 J Neuroinflammationen
dc.identifier.issn1742-2094en
dc.identifier.pmid26819220en
dc.identifier.doi10.1186/s12974-016-0487-9en
dc.identifier.urihttp://hdl.handle.net/10033/601142en
dc.description.abstractAlthough type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.en
dc.language.isoenen
dc.titleType I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of neuroinflammationen

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