Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.

2.50
Hdl Handle:
http://hdl.handle.net/10033/601218
Title:
Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.
Authors:
Leist, Sarah R; Pilzner, Carolin; van den Brand, Judith M A; Dengler, Leonie; Geffers, Robert ( 0000-0003-4409-016X ) ; Kuiken, Thijs; Balling, Rudi; Kollmus, Heike; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
Influenza A virus is a zoonotic pathogen that poses a major threat to human and animal health. The severe course of influenza infection is not only influenced by viral virulence factors but also by individual differences in the host response. To determine the extent to which the genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mouse strains.
Affiliation:
Helmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.
Citation:
Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. 2016, 17 (1):143 BMC Genomics
Journal:
BMC genomics
Issue Date:
2016
URI:
http://hdl.handle.net/10033/601218
DOI:
10.1186/s12864-016-2483-y
PubMed ID:
26921172
Type:
Article
Language:
en
ISSN:
1471-2164
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorLeist, Sarah Ren
dc.contributor.authorPilzner, Carolinen
dc.contributor.authorvan den Brand, Judith M Aen
dc.contributor.authorDengler, Leonieen
dc.contributor.authorGeffers, Roberten
dc.contributor.authorKuiken, Thijsen
dc.contributor.authorBalling, Rudien
dc.contributor.authorKollmus, Heikeen
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2016-03-11T14:59:02Zen
dc.date.available2016-03-11T14:59:02Zen
dc.date.issued2016en
dc.identifier.citationInfluenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice. 2016, 17 (1):143 BMC Genomicsen
dc.identifier.issn1471-2164en
dc.identifier.pmid26921172en
dc.identifier.doi10.1186/s12864-016-2483-yen
dc.identifier.urihttp://hdl.handle.net/10033/601218en
dc.description.abstractInfluenza A virus is a zoonotic pathogen that poses a major threat to human and animal health. The severe course of influenza infection is not only influenced by viral virulence factors but also by individual differences in the host response. To determine the extent to which the genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mouse strains.en
dc.language.isoenen
dc.titleInfluenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research (HZI), Inhoffenstraße 7, 38124 Braunschweig, Germany.en
dc.identifier.journalBMC genomicsen

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