2.50
Hdl Handle:
http://hdl.handle.net/10033/604728
Title:
LC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens
Authors:
Thumfart, Jörg Oliver; Abidi, Nada; Mindt, Sonani; Costani, Victor; Hofheinz, Ralf; Klawonn, Frank ( 0000-0001-9613-182X ) ; Findeisen, Peter
Abstract:
Preanalytical variations have major impact on most biological assays. Specifically MS-based multiparametric proteomics analyses of blood specimens are seriously affected by limited protein stability due to high intrinsic proteolytic activity of serum and plasma. However, the direct analysis of sample quality (DASQ) for serum specimens is not readily available. Here we propose the mass spectrometry based monitoring of peptide patterns that are ex vivo changing in a time dependent manner to alleviate these constrains.
Affiliation:
1Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
Citation:
LC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens 2015, 08 (05) Journal of Proteomics & Bioinformatics
Journal:
Journal of Proteomics & Bioinformatics
Issue Date:
4-May-2015
URI:
http://hdl.handle.net/10033/604728
DOI:
10.4172/jpb.1000356
Additional Links:
http://www.omicsonline.org/open-access/lcms-based-monitoring-of-endogenous-decay-markers-for-qualityassessment-of-serum-specimens-jpb-1000356.php?aid=51836
Type:
Article
ISSN:
0974276X
Appears in Collections:
publications of the research group cellular proteom research (CPRO)

Full metadata record

DC FieldValue Language
dc.contributor.authorThumfart, Jörg Oliveren
dc.contributor.authorAbidi, Nadaen
dc.contributor.authorMindt, Sonanien
dc.contributor.authorCostani, Victoren
dc.contributor.authorHofheinz, Ralfen
dc.contributor.authorKlawonn, Franken
dc.contributor.authorFindeisen, Peteren
dc.date.accessioned2016-04-07T11:13:38Zen
dc.date.available2016-04-07T11:13:38Zen
dc.date.issued2015-05-04en
dc.identifier.citationLC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimens 2015, 08 (05) Journal of Proteomics & Bioinformaticsen
dc.identifier.issn0974276Xen
dc.identifier.doi10.4172/jpb.1000356en
dc.identifier.urihttp://hdl.handle.net/10033/604728en
dc.description.abstractPreanalytical variations have major impact on most biological assays. Specifically MS-based multiparametric proteomics analyses of blood specimens are seriously affected by limited protein stability due to high intrinsic proteolytic activity of serum and plasma. However, the direct analysis of sample quality (DASQ) for serum specimens is not readily available. Here we propose the mass spectrometry based monitoring of peptide patterns that are ex vivo changing in a time dependent manner to alleviate these constrains.en
dc.relation.urlhttp://www.omicsonline.org/open-access/lcms-based-monitoring-of-endogenous-decay-markers-for-qualityassessment-of-serum-specimens-jpb-1000356.php?aid=51836en
dc.titleLC/MS Based Monitoring of Endogenous Decay Markers for Quality Assessment of Serum Specimensen
dc.typeArticleen
dc.contributor.department1Institute for Clinical Chemistry, Medical Faculty Mannheim of the University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germanyen
dc.identifier.journalJournal of Proteomics & Bioinformaticsen
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