2.50
Hdl Handle:
http://hdl.handle.net/10033/606592
Title:
Atypical IκB proteins in immune cell differentiation and function.
Authors:
Annemann, Michaela; Plaza-Sirvent, Carlos; Schuster, Marc; Katsoulis-Dimitriou, Konstantinos; Kliche, Stefanie; Schraven, Burkhart; Schmitz, Ingo
Abstract:
The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.
Citation:
Atypical IκB proteins in immune cell differentiation and function. 2016, 171:26-35 Immunol. Lett.
Journal:
Immunology letters
Issue Date:
Mar-2016
URI:
http://hdl.handle.net/10033/606592
DOI:
10.1016/j.imlet.2016.01.006
PubMed ID:
26804211
Type:
Article
Language:
en
ISSN:
1879-0542
Appears in Collections:
publications of the AG system-oriented immunologyand infection research (SIME)

Full metadata record

DC FieldValue Language
dc.contributor.authorAnnemann, Michaelaen
dc.contributor.authorPlaza-Sirvent, Carlosen
dc.contributor.authorSchuster, Marcen
dc.contributor.authorKatsoulis-Dimitriou, Konstantinosen
dc.contributor.authorKliche, Stefanieen
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorSchmitz, Ingoen
dc.date.accessioned2016-04-22T13:31:47Zen
dc.date.available2016-04-22T13:31:47Zen
dc.date.issued2016-03en
dc.identifier.citationAtypical IκB proteins in immune cell differentiation and function. 2016, 171:26-35 Immunol. Lett.en
dc.identifier.issn1879-0542en
dc.identifier.pmid26804211en
dc.identifier.doi10.1016/j.imlet.2016.01.006en
dc.identifier.urihttp://hdl.handle.net/10033/606592en
dc.description.abstractThe NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.en
dc.language.isoenen
dc.titleAtypical IκB proteins in immune cell differentiation and function.en
dc.typeArticleen
dc.identifier.journalImmunology lettersen

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