Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.

2.50
Hdl Handle:
http://hdl.handle.net/10033/606947
Title:
Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.
Authors:
Leist, Sarah R; Kollmus, Heike; Hatesuer, Bastian; Lambertz, Ruth L O; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
Previously, we performed a quantitative trait locus (QTL) mapping study in BXD recombinant inbred mice to identify host genetic factors that confer resistance to influenza A virus infection. We found Lst1 (leukocyte specific transcript 1) as one of the most promising candidate genes in the Qivr17-2 locus because it is non-functional in DBA/2 J mice. Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional immune-regulatory functions. Here, we evaluated the relevance of LST1 for the host response to influenza A infection in B6-Lst1 (-/-) mutant mice.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice. 2016, 13 (1):17 Virol. J.
Journal:
Virology journal
Issue Date:
2016
URI:
http://hdl.handle.net/10033/606947
DOI:
10.1186/s12985-016-0471-0
PubMed ID:
26817701
Type:
Article
Language:
en
ISSN:
1743-422X
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorLeist, Sarah Ren
dc.contributor.authorKollmus, Heikeen
dc.contributor.authorHatesuer, Bastianen
dc.contributor.authorLambertz, Ruth L Oen
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2016-04-25T13:15:55Zen
dc.date.available2016-04-25T13:15:55Zen
dc.date.issued2016en
dc.identifier.citationLst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice. 2016, 13 (1):17 Virol. J.en
dc.identifier.issn1743-422Xen
dc.identifier.pmid26817701en
dc.identifier.doi10.1186/s12985-016-0471-0en
dc.identifier.urihttp://hdl.handle.net/10033/606947en
dc.description.abstractPreviously, we performed a quantitative trait locus (QTL) mapping study in BXD recombinant inbred mice to identify host genetic factors that confer resistance to influenza A virus infection. We found Lst1 (leukocyte specific transcript 1) as one of the most promising candidate genes in the Qivr17-2 locus because it is non-functional in DBA/2 J mice. Several studies have proposed that LST1 plays a role in the immune response to inflammatory diseases in humans and has additional immune-regulatory functions. Here, we evaluated the relevance of LST1 for the host response to influenza A infection in B6-Lst1 (-/-) mutant mice.en
dc.language.isoenen
dc.titleLst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalVirology journalen

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