2.50
Hdl Handle:
http://hdl.handle.net/10033/611238
Title:
Cellular Antiviral Factors that Target Particle Infectivity of HIV-1.
Authors:
Goffinet, Christine
Abstract:
In the past decade, the identification and characterization of antiviral genes with the ability to interfere with virus replication has established cell-intrinsic innate immunity as a third line of antiviral defense in addition to adaptive and classical innate immunity. Understanding how cellular factors have evolved to inhibit HIV-1 reveals particularly vulnerable points of the viral replication cycle. Many, but not all, antiviral proteins share type I interferon-upregulated expression and sensitivity to viral counteraction or evasion measures. Whereas well-established restriction factors interfere with early post-entry steps and release of HIV-1, recent research has revealed a diverse set of proteins that reduce the infectious quality of released particles using individual, to date poorly understood modes of action. These include induction of paucity of mature glycoproteins in nascent virions or self-incorporation into the virus particle, resulting in poor infectiousness of the virion and impaired spread of the infection.
Affiliation:
TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Citation:
Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. 2016, 14 (3):211-6 Curr. HIV Res.
Journal:
Current HIV research
Issue Date:
2016
URI:
http://hdl.handle.net/10033/611238
PubMed ID:
26674651
Type:
Article
Language:
en
ISSN:
1873-4251
Appears in Collections:
publications of the research group innate immunity and viral evasion ([TC] AIVE)

Full metadata record

DC FieldValue Language
dc.contributor.authorGoffinet, Christineen
dc.date.accessioned2016-05-31T13:07:52Zen
dc.date.available2016-05-31T13:07:52Zen
dc.date.issued2016en
dc.identifier.citationCellular Antiviral Factors that Target Particle Infectivity of HIV-1. 2016, 14 (3):211-6 Curr. HIV Res.en
dc.identifier.issn1873-4251en
dc.identifier.pmid26674651en
dc.identifier.urihttp://hdl.handle.net/10033/611238en
dc.description.abstractIn the past decade, the identification and characterization of antiviral genes with the ability to interfere with virus replication has established cell-intrinsic innate immunity as a third line of antiviral defense in addition to adaptive and classical innate immunity. Understanding how cellular factors have evolved to inhibit HIV-1 reveals particularly vulnerable points of the viral replication cycle. Many, but not all, antiviral proteins share type I interferon-upregulated expression and sensitivity to viral counteraction or evasion measures. Whereas well-established restriction factors interfere with early post-entry steps and release of HIV-1, recent research has revealed a diverse set of proteins that reduce the infectious quality of released particles using individual, to date poorly understood modes of action. These include induction of paucity of mature glycoproteins in nascent virions or self-incorporation into the virus particle, resulting in poor infectiousness of the virion and impaired spread of the infection.en
dc.language.isoenen
dc.titleCellular Antiviral Factors that Target Particle Infectivity of HIV-1.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalCurrent HIV researchen

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