Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

2.50
Hdl Handle:
http://hdl.handle.net/10033/613872
Title:
Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.
Authors:
Rueda, Fabián; Céspedes, María Virtudes; Sánchez-Chardi, Alejandro; Seras-Franzoso, Joaquin; Pesarrodona, Mireia; Ferrer-Miralles, Neus; Vázquez, Esther; Rinas, Ursula; Unzueta, Ugutz; Mamat, Uwe; Mangues, Ramón; García-Fruitós, Elena; Villaverde, Antonio
Abstract:
Production of recombinant drugs in process-friendly endotoxin-free bacterial factories targets to a lessened complexity of the purification process combined with minimized biological hazards during product application. The development of nanostructured recombinant materials in innovative nanomedical activities expands such a need beyond plain functional polypeptides to complex protein assemblies. While Escherichia coli has been recently modified for the production of endotoxin-free proteins, no data has been so far recorded regarding how the system performs in the fabrication of smart nanostructured materials.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli. 2016, 15 (1):59 Microb. Cell Fact.
Journal:
Microbial cell factories
Issue Date:
2016
URI:
http://hdl.handle.net/10033/613872
DOI:
10.1186/s12934-016-0457-z
PubMed ID:
27059706
Type:
Article
Language:
en
ISSN:
1475-2859
Appears in Collections:
publications of the research group recombinant protein expression (RPEX)

Full metadata record

DC FieldValue Language
dc.contributor.authorRueda, Fabiánen
dc.contributor.authorCéspedes, María Virtudesen
dc.contributor.authorSánchez-Chardi, Alejandroen
dc.contributor.authorSeras-Franzoso, Joaquinen
dc.contributor.authorPesarrodona, Mireiaen
dc.contributor.authorFerrer-Miralles, Neusen
dc.contributor.authorVázquez, Estheren
dc.contributor.authorRinas, Ursulaen
dc.contributor.authorUnzueta, Ugutzen
dc.contributor.authorMamat, Uween
dc.contributor.authorMangues, Ramónen
dc.contributor.authorGarcía-Fruitós, Elenaen
dc.contributor.authorVillaverde, Antonioen
dc.date.accessioned2016-06-21T14:12:13Zen
dc.date.available2016-06-21T14:12:13Zen
dc.date.issued2016en
dc.identifier.citationStructural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli. 2016, 15 (1):59 Microb. Cell Fact.en
dc.identifier.issn1475-2859en
dc.identifier.pmid27059706en
dc.identifier.doi10.1186/s12934-016-0457-zen
dc.identifier.urihttp://hdl.handle.net/10033/613872en
dc.description.abstractProduction of recombinant drugs in process-friendly endotoxin-free bacterial factories targets to a lessened complexity of the purification process combined with minimized biological hazards during product application. The development of nanostructured recombinant materials in innovative nanomedical activities expands such a need beyond plain functional polypeptides to complex protein assemblies. While Escherichia coli has been recently modified for the production of endotoxin-free proteins, no data has been so far recorded regarding how the system performs in the fabrication of smart nanostructured materials.en
dc.language.isoenen
dc.titleStructural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMicrobial cell factoriesen

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