What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies.

2.50
Hdl Handle:
http://hdl.handle.net/10033/614444
Title:
What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies.
Authors:
Betran, Ana Pilar; Torloni, Maria Regina; Zhang, Jun; Ye, Jiangfeng; Mikolajczyk, Rafael ( 0000-0003-1271-7204 ) ; Deneux-Tharaux, Catherine; Oladapo, Olufemi Taiwo; Souza, João Paulo; Tunçalp, Özge; Vogel, Joshua Peter; Gülmezoglu, Ahmet Metin
Abstract:
In 1985, WHO stated that there was no justification for caesarean section (CS) rates higher than 10-15% at population-level. While the CS rates worldwide have continued to increase in an unprecedented manner over the subsequent three decades, concern has been raised about the validity of the 1985 landmark statement. We conducted a systematic review to identify, critically appraise and synthesize the analyses of the ecologic association between CS rates and maternal, neonatal and infant outcomes. Four electronic databases were searched for ecologic studies published between 2000 and 2014 that analysed the possible association between CS rates and maternal, neonatal or infant mortality or morbidity. Two reviewers performed study selection, data extraction and quality assessment independently. We identified 11,832 unique citations and eight studies were included in the review. Seven studies correlated CS rates with maternal mortality, five with neonatal mortality, four with infant mortality, two with LBW and one with stillbirths. Except for one, all studies were cross-sectional in design and five were global analyses of national-level CS rates versus mortality outcomes. Although the overall quality of the studies was acceptable; only two studies controlled for socio-economic factors and none controlled for clinical or demographic characteristics of the population. In unadjusted analyses, authors found a strong inverse relationship between CS rates and the mortality outcomes so that maternal, neonatal and infant mortality decrease as CS rates increase up to a certain threshold. In the eight studies included in this review, this threshold was at CS rates between 9 and 16%. However, in the two studies that adjusted for socio-economic factors, this relationship was either weakened or disappeared after controlling for these confounders. CS rates above the threshold of 9-16% were not associated with decreases in mortality outcomes regardless of adjustments. Our findings could be interpreted to mean that at CS rates below this threshold, socio-economic development may be driving the ecologic association between CS rates and mortality. On the other hand, at rates higher than this threshold, there is no association between CS and mortality outcomes regardless of adjustment. The ecological association between CS rates and relevant morbidity outcomes needs to be evaluated before drawing more definite conclusions at population level.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
What is the optimal rate of caesarean section at population level? A systematic review of ecologic studies. 2015, 12:57 Reprod Health
Journal:
Reproductive health
Issue Date:
2015
URI:
http://hdl.handle.net/10033/614444
DOI:
10.1186/s12978-015-0043-6
PubMed ID:
26093498
Type:
Article
Language:
en
ISSN:
1742-4755
Appears in Collections:
Publications of the AG (ESME)

Full metadata record

DC FieldValue Language
dc.contributor.authorBetran, Ana Pilaren
dc.contributor.authorTorloni, Maria Reginaen
dc.contributor.authorZhang, Junen
dc.contributor.authorYe, Jiangfengen
dc.contributor.authorMikolajczyk, Rafaelen
dc.contributor.authorDeneux-Tharaux, Catherineen
dc.contributor.authorOladapo, Olufemi Taiwoen
dc.contributor.authorSouza, João Pauloen
dc.contributor.authorTunçalp, Özgeen
dc.contributor.authorVogel, Joshua Peteren
dc.contributor.authorGülmezoglu, Ahmet Metinen
dc.date.accessioned2016-06-23T13:35:01Z-
dc.date.available2016-06-23T13:35:01Z-
dc.date.issued2015-
dc.identifier.citationWhat is the optimal rate of caesarean section at population level? A systematic review of ecologic studies. 2015, 12:57 Reprod Healthen
dc.identifier.issn1742-4755-
dc.identifier.pmid26093498-
dc.identifier.doi10.1186/s12978-015-0043-6-
dc.identifier.urihttp://hdl.handle.net/10033/614444-
dc.description.abstractIn 1985, WHO stated that there was no justification for caesarean section (CS) rates higher than 10-15% at population-level. While the CS rates worldwide have continued to increase in an unprecedented manner over the subsequent three decades, concern has been raised about the validity of the 1985 landmark statement. We conducted a systematic review to identify, critically appraise and synthesize the analyses of the ecologic association between CS rates and maternal, neonatal and infant outcomes. Four electronic databases were searched for ecologic studies published between 2000 and 2014 that analysed the possible association between CS rates and maternal, neonatal or infant mortality or morbidity. Two reviewers performed study selection, data extraction and quality assessment independently. We identified 11,832 unique citations and eight studies were included in the review. Seven studies correlated CS rates with maternal mortality, five with neonatal mortality, four with infant mortality, two with LBW and one with stillbirths. Except for one, all studies were cross-sectional in design and five were global analyses of national-level CS rates versus mortality outcomes. Although the overall quality of the studies was acceptable; only two studies controlled for socio-economic factors and none controlled for clinical or demographic characteristics of the population. In unadjusted analyses, authors found a strong inverse relationship between CS rates and the mortality outcomes so that maternal, neonatal and infant mortality decrease as CS rates increase up to a certain threshold. In the eight studies included in this review, this threshold was at CS rates between 9 and 16%. However, in the two studies that adjusted for socio-economic factors, this relationship was either weakened or disappeared after controlling for these confounders. CS rates above the threshold of 9-16% were not associated with decreases in mortality outcomes regardless of adjustments. Our findings could be interpreted to mean that at CS rates below this threshold, socio-economic development may be driving the ecologic association between CS rates and mortality. On the other hand, at rates higher than this threshold, there is no association between CS and mortality outcomes regardless of adjustment. The ecological association between CS rates and relevant morbidity outcomes needs to be evaluated before drawing more definite conclusions at population level.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshCesarean Sectionen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant Mortalityen
dc.subject.meshInfant, Newbornen
dc.subject.meshMaternal Mortalityen
dc.subject.meshMorbidityen
dc.subject.meshPregnancyen
dc.subject.meshPregnancy Outcomeen
dc.subject.meshSocioeconomic Factorsen
dc.subject.meshWorld Health Organizationen
dc.titleWhat is the optimal rate of caesarean section at population level? A systematic review of ecologic studies.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalReproductive healthen

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