INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community.

2.50
Hdl Handle:
http://hdl.handle.net/10033/615668
Title:
INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community.
Authors:
INFRAFRONTIER Consortium; Meehan, T. F.; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
The laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
INFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. 2015, 43 (Database issue):D1171-5 Nucleic Acids Res.
Journal:
Nucleic acids research
Issue Date:
Jan-2015
URI:
http://hdl.handle.net/10033/615668
DOI:
10.1093/nar/gku1193
PubMed ID:
25414328
Type:
Article
Language:
en
ISSN:
1362-4962
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorINFRAFRONTIER Consortiumen
dc.contributor.authorMeehan, T. F.en
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2016-07-07T12:10:46Z-
dc.date.available2016-07-07T12:10:46Z-
dc.date.issued2015-01-
dc.identifier.citationINFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community. 2015, 43 (Database issue):D1171-5 Nucleic Acids Res.en
dc.identifier.issn1362-4962-
dc.identifier.pmid25414328-
dc.identifier.doi10.1093/nar/gku1193-
dc.identifier.urihttp://hdl.handle.net/10033/615668-
dc.description.abstractThe laboratory mouse is a key model organism to investigate mechanism and therapeutics of human disease. The number of targeted genetic mouse models of disease is growing rapidly due to high-throughput production strategies employed by the International Mouse Phenotyping Consortium (IMPC) and the development of new, more efficient genome engineering techniques such as CRISPR based systems. We have previously described the European Mouse Mutant Archive (EMMA) resource and how this international infrastructure provides archiving and distribution worldwide for mutant mouse strains. EMMA has since evolved into INFRAFRONTIER (http://www.infrafrontier.eu), the pan-European research infrastructure for the systemic phenotyping, archiving and distribution of mouse disease models. Here we describe new features including improved search for mouse strains, support for new embryonic stem cell resources, access to training materials via a comprehensive knowledgebase and the promotion of innovative analytical and diagnostic techniques.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshDatabases, Geneticen
dc.subject.meshEmbryonic Stem Cellsen
dc.subject.meshInterneten
dc.subject.meshKnowledge Basesen
dc.subject.meshMice, Mutant Strainsen
dc.subject.meshModels, Animalen
dc.subject.meshPhenotypeen
dc.titleINFRAFRONTIER--providing mutant mouse resources as research tools for the international scientific community.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNucleic acids researchen

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