2.50
Hdl Handle:
http://hdl.handle.net/10033/616990
Title:
Early changes in the metabolic profile of activated CD8(+) T cells.
Authors:
Cammann, Clemens; Rath, Alexander; Reichl, Udo; Lingel, Holger; Brunner-Weinzierl, Monika; Simeoni, Luca; Schraven, Burkhart; Lindquist, Jonathan A
Abstract:
Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we investigated changes of metabolic intermediates indicating for crucial metabolic pathways reflecting the status of T cells. Moreover we analyzed possible regulatory molecules required for the initiation of the metabolic changes.
Affiliation:
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Early changes in the metabolic profile of activated CD8(+) T cells. 2016, 17 (1):28 BMC Cell Biol.
Journal:
BMC cell biology
Issue Date:
2016
URI:
http://hdl.handle.net/10033/616990
DOI:
10.1186/s12860-016-0104-x
PubMed ID:
27387758
Type:
Article
Language:
en
ISSN:
1471-2121
Appears in Collections:
publications of the department of immune control (IMMK)

Full metadata record

DC FieldValue Language
dc.contributor.authorCammann, Clemensen
dc.contributor.authorRath, Alexanderen
dc.contributor.authorReichl, Udoen
dc.contributor.authorLingel, Holgeren
dc.contributor.authorBrunner-Weinzierl, Monikaen
dc.contributor.authorSimeoni, Lucaen
dc.contributor.authorSchraven, Burkharten
dc.contributor.authorLindquist, Jonathan Aen
dc.date.accessioned2016-07-15T09:40:17Z-
dc.date.available2016-07-15T09:40:17Z-
dc.date.issued2016-
dc.identifier.citationEarly changes in the metabolic profile of activated CD8(+) T cells. 2016, 17 (1):28 BMC Cell Biol.en
dc.identifier.issn1471-2121-
dc.identifier.pmid27387758-
dc.identifier.doi10.1186/s12860-016-0104-x-
dc.identifier.urihttp://hdl.handle.net/10033/616990-
dc.description.abstractAntigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we investigated changes of metabolic intermediates indicating for crucial metabolic pathways reflecting the status of T cells. Moreover we analyzed possible regulatory molecules required for the initiation of the metabolic changes.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleEarly changes in the metabolic profile of activated CD8(+) T cells.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalBMC cell biologyen

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