Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.

2.50
Hdl Handle:
http://hdl.handle.net/10033/617985
Title:
Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.
Authors:
Mostaghaci, Babak; Loretz, Brigitta; Lehr, Claus-Michael
Abstract:
Calcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.
Affiliation:
Helmholtz Institut f?r Pharmazeutische Forschung Saarland, Universit?tscampus E8.1, 66123 Saarbr?cken, Germany.
Citation:
Calcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities. 2016, 22 (11):1529-33 Curr. Pharm. Des.
Journal:
Current pharmaceutical design
Issue Date:
2016
URI:
http://hdl.handle.net/10033/617985
PubMed ID:
26654437
Type:
Article
Language:
en
ISSN:
1873-4286
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorMostaghaci, Babaken
dc.contributor.authorLoretz, Brigittaen
dc.contributor.authorLehr, Claus-Michaelen
dc.date.accessioned2016-08-05T13:38:56Z-
dc.date.available2016-08-05T13:38:56Z-
dc.date.issued2016-
dc.identifier.citationCalcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities. 2016, 22 (11):1529-33 Curr. Pharm. Des.en
dc.identifier.issn1873-4286-
dc.identifier.pmid26654437-
dc.identifier.urihttp://hdl.handle.net/10033/617985-
dc.description.abstractCalcium phosphate system has been used widely in in vitro gene delivery for almost four decades. Excellent biocompatibility and simple application have motivated the researchers to always consider this system in their transfection experiments. However, there was a major drawback regarding the low transfection efficiency of calcium phosphate. Hence, there have been many efforts in order to increase the gene delivery potential of this system. In this paper, the application of calcium phosphate in gene delivery is introduced. Moreover, the recent progresses in the application of calcium phosphate in the delivery of (oligo)nucleotides and different approaches to improve the properties of this system are reviewed.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleCalcium Phosphate System for Gene Delivery: Historical Background and Emerging Opportunities.en
dc.typeArticleen
dc.contributor.departmentHelmholtz Institut f?r Pharmazeutische Forschung Saarland, Universit?tscampus E8.1, 66123 Saarbr?cken, Germany.en
dc.identifier.journalCurrent pharmaceutical designen

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